Comparative Response of Normal and Cirrhotic Rats to Intravenously Injected Bacteria.

Rutenburg, Alexander M.; Eh, Sonnenblick; Koven, Irving H.; Schweinburg, Fritz B.; Fine, Jacob

doi:10.3181/00379727-101-24910

Cited by 42 publications

(7 citation statements)

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“…A reduced hepatic RES activity has been described in cirrhotic patients [3,7,11] and animals [15,18]. The mechanisms of im paired RES activity in cirrhosis are not well known; responsible factors are either a re duced blood flow to RES hepatic cells or a defective activity of RES hepatic cells.…”

Section: Discussionmentioning

confidence: 99%

Decreased Reticuloendothelial Phagocytic Capacity in Cirrhotic and Portacaval Shunt Rats

Capron-Laudereau¹,

Gugenheim²,

Gigou³

et al. 1987

Eur Surg Res

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In cirrhosis, the phagocytic function of the reticuloendothelial system (RES) is decreased. In order to investigate the mechanisms of the hepatic reduced phagocytic activity present in cirrhosis, the hepatic and splenic uptake of ⁵¹Cr sheep red blood cells (SRBC) and of colloidal carbon was measured in three groups of Sprague-Dawley rats. Group 1 consisted of 42 control rats, group 2 of 36 rats with end-to-side portacaval shunt and group 3 of 24 rats with carbon tetrachloride-induced cirrhosis. The hepatic uptake of ⁵¹Cr SRBC and of colloidal carbon was significantly (p < 0.001) reduced in cirrhotic rats (group 3). Conversely, in rats with a portacaval shunt and a noncirrhotic liver (group 2), the hepatic uptake of ⁵¹Cr SRBC was moderately reduced, whereas the colloidal carbon hepatic uptake was not found to be decreased. These results suggest that the decreased RES phagocytic activity observed in cirrhotic rats is only partially due to portacaval shunt and that an intrinsic defective activity of hepatic phagocytic cells is probably present.

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Section: Discussionmentioning

confidence: 99%

Decreased Reticuloendothelial Phagocytic Capacity in Cirrhotic and Portacaval Shunt Rats

Capron-Laudereau¹,

Gugenheim²,

Gigou³

et al. 1987

Eur Surg Res

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“…(2) The hepatic reticuloendothelial cell in cirrhotic patients has an impaired ca pacity to kill phagocytized bacteria [6].…”

Section: Discussionmentioning

confidence: 99%

Spontaneous Bacterial Pleuritis in a Patient with Cirrhosis

Streifler¹,

Pitlik²,

Dux³

et al. 1984

Respiration

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Empyema of the left pleural cavity developed suddenly in a nonalcoholic cirrhotic patient. Cultures of the pleural fluid under anaerobic conditions grew Clostridium perfringens, an organism normally found in the enteric flora. The infection developed in an old pleural effusion. Since there was no evidence of trauma, necrotizing pneumonitis or subphrenic infection, spontaneous bacterial pleuritis is proposed. Bacterial infections are frequent among cirrhotic patients. The ascitic fluid may be contaminated by blood-borne enteric bacteria [1]. The resulting ‘spontaneous bacterial peritonitis’ is characterized by an abrupt onset of fever, chills, abdominal pain and an increase in the amount of ascitic fluid [1]. The pleural cavity counterpart to ‘spontaneous bacterial peritonitis’ has not been described. We report the case of a cirrhotic patient who suddenly developed a clostridial empyema in the left pleural cavity despite the absence of trauma, necrotizing pneumonitis or subphrenic infection

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“…Bacteraemia caused by enteric organisms is a well recognised complication of patients with chronic liver disease.1 3 Indeed in at least 50% of patients the same organism is simultaneously isolated from blood and ascites, whilst in others blood cultures are positive when ascitic fluid is sterile.5 15 Clinical and experimental data suggest that impaired function of the reticulo endothelial system (RE), in particular the Kupffer cells of the liver, together with intrahepatic and portasystemic shunting of blood, is important in the genesis of bacteraemia and SBP. [16][17][18][19] Enteric bacteria normally removed by the hepatic RE system would then pass directly into the systemic circulation and could give rise to SBP. Against this hypothesis is the observation that several studies have failed to isolate organisms from the portal blood of cirrhotic patients.2>2' Whether peritonitis is a primary factor, or a consequence of bacteraemia is thus unclear.…”

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confidence: 99%