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Whole heated clear apple juice subjected to a modified Salmonella mutagenicity assay did not show any mutagenic response. However, when fractionated, one fraction obtained from gel filtration did show a dose-related mutagenic response. This suggested the presence of antimutagenic factors. The Ames standard mutagenicity test was used to investigate the antimutagenic activity of apple juice samples against the direct acting mutagens nitroquinoline-N-oxide (NQO) and N-methyl-N'nitro-N-nitrosoguanidine (MNNG). There was a dose and heat load dependent reduction in the mutagenicity of both mutagens, indicating the presence of antimutagenic factors.

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