ABSTRAKPenelitian ini bertujuan untuk mengetahui granul effervescent ekstrak daun binahong yang diformulasikan telah memenuhi persyaratan dan menentukan formulasi granul effervescent yang terbaik. Penelitian ini merupakan penelitian deskriptif eksperimental dengan pengambilan data dari evaluasi granul effervescent. Untuk membuat sediaan granul effervescent terlebih dahulu dilakukan ekstraksi daun binahong. Ekstrak diperoleh dari metode maserasi menggunakan pelarut etanol 70%. Formula granul effervescent dibuat sebanyak tiga buah dengan variasi konsentrasi ekstrak F1 7,4%; F2 14,8%; dan F3 22,2%. Granul effervescent daun binahong dibuat dengan menggunakan metode granulasi basah dan dilakukan evaluasi mutu fisik granul meliputi uji organoleptik, kadar air, volume tuang, volume guncang, daya alir, waktu dispersi, dan pH. Hasil penelitian menunjukkan semua granul effervescent ekstrak daun binahong (Anredera cordifolia (Tenore) Steen.) telah memenuhi persyaratan granul yang baik. Dari ketiga formulasi, granul terbaik adalah F3, di mana memiliki nilai terbaik pada pengujian kadar air, uji volume guncang, daya alir, dan pH. ABSTRACTThe purpose of this research are to find out whether the formulation of effervescent granules from binahong leaves extract has met the standards for effervescent granules and determine the best formulation of effervescent granules. This research is descriptive experimental with data collection from evaluation of effervescent granules. To be able to make effervescent granules, extraction of binahong leaves must be made first. The extracts resulted from a maseration method with 70% ethanol. The effervescent granules formulation were made by 3 design based on their concentration F1 7.4%; F2 14.8%; and F3 22.2%. Effervescent granules of binahong leaves extract are prepared by using wet granulation method. Several physical tests were carried out on the results of effervescent granules of binahong leaves, including organoleptic test, moisture content test, pour volume test, volume of shringkage test, flow capacity test, dispersion test, and pH. The test results showed that all the effervescent granules of binahong leaves (Anredera cordifolia (Tenore) Steen.) have met the standard requirements as good granules. The third formula became the best formulation, With the best value in moisture content test, volume of shringkage test, flow capacity test, and pH.
Several plant species have been used for the treatment of diabetes. Research on plants that can be used to treat diabetes such as Cinnamomum cassia and Cinnamomum zeylanicum, Piper sarmentosum Roxb, Nelumbo nucifera, Ceiba petandra, Memecylon malabaricum. Broccoli (Brassica oleracea L var italics) is a flower of vegetables like cabbage plants. Broccoli juice is made capable of direct and indirect effects on the reduction of blood LDL; the indirect effect is by repairing pancreatic beta cells and increasing insulin sensitivity. The purpose of this study was to determine whether broccoli has activity as antidiabetic. The subjects consisted of 15 mice induced with nicotinamide 70 mg/kg BW and Stz 150 mg/kg BW. Diabetic mice were divided into the positive control group (glibenclamide), negative control group (CMC Na) and three treatment groups. The test material is broccoli extract dose 75 mg/kg BW, 150 mg /kg BW and 300 mg/kg BW given peroral for 14 days. Anova test results showed that there was a significant difference in the average percentage of decreased blood glucose levels in all treatments. The result of Post Hock Tukey HSD test with a 95% confidence level showed a significant difference in the negative control group compared with positive control group and extract 300 mg/kg BW. This result shows that positive control group and extracts 300 mg/kg body weight have an activity to decrease blood glucose level.
Traditional medicine is a mixture of various types of plant parts in an area, so that local wisdom related to traditional medicine needs to be studied, preserved, and developed. This requires supporting data, namely in the form of written documentation and documented images with the aim of knowing various types of medicinal plants, types of diseases, how to mix, and how to treat them. This type of research is a descriptive qualitative research with snowball sampling technique. The inclusion criteria in this study, among others: the residents of the Secang District who have sufficient knowledge and experience in traditional medicine, are willing to be informants in the study, people who are over 30 years old. The results showed that the community in 5 villages, Secang District, Magelang Regency used 107 species of medicinal plants from 54 families. The plant parts used are leaves, stems, roots, flowers, seeds, rhizomes, fruits, tubers, all plants, bark, wood, and fruit skins. The results of the above calculations obtained sample results for 5 villages, which amounted to 387 respondents with a 95% confidence level. ICF analysis is used to determine the level of homogeneity between the information provided by the respondents. In this study, there were a total of 80 types of disease, based on the results of the ICF calculation, the value that was close to 1 was 45 efficacy, while the ICF value that was close to 0 was 35 efficacy
One of the subdistricts in Magelang regency which has a problem with the Diabetes Mellitus Disease in the Sawangan District, especially in the area of Sawangan Public Health Center, namely Kalangan, Gondowangi Village. So as the resolve this problem must be done various efforts of early detection in solve the problem of Diabetes Mellitus. One of the solutions to solve this problem is the dissemination as early detection and utilization of Diabetes Mellitus herbal plants. With the socialization and utilization of herbal medicinal plants on Diabetes Mellitus, it is expected that the community can pay attention to healthy lifestyles in the future, reduce the incidence of Diabetes Mellitus in the community and can take advantage of herbal treatments around the house so that people are not dependent on chemical or synthetic treatments that have side effects in the body. Keywords: diabetes mellitus; early detection; herbal medicinal plants Abstrak: Salah satu Kecamatan yang ada di Kabupaten Magelang yang terdapat masalah Diabetes Mellitus yaitu Kecamatan Sawangan khususnya di wilayah kerja Puskemas Sawangan II yaitu Dusun Kalangan desa Gondowangi. Sehingga untuk mengatasi hal tersebut harus di lakukan berbagai upaya Deteksi Dini dalam mengatasi masalah Diabetes Mellitus. Salah satu dalam mengatasi masalah tersebut di lakukan sosialisasi sebagai bagian deteksi dini Diabetes Mellitus dan pemanfaatan tanaman herbal Diabetes Melitus. Dengan di adakannya sosialisasi dan pemanfaatan tanaman obat keluarga (TOGA) tentang Diabetes Melitus di harapkan mayarakat kedepannya dapat memperhatikan pola hidup sehat, mengurangi kejadian penyakit Diabetes Melitus di masyarakat dan dapat memanfaatkan pengobatan herbal di sekitar rumah agar masyarakat tidak ketergantungan dengan pengobatan kimia atau sintetik yang mempunyai efek samping dalam tubuh. Kata kunci: deteksi dini; diabetes mellitus; tanaman obat keluarga
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.