Metal complexes with organelle specificity and potent but selective cytotoxicity are highly desirable. A novel series of triphenylstannyl 4-((arylimino)methyl)benzoates (2-8) were obtained by the reactions of triphenylstannyl 4-formylbenzoate [PhSn(L)] 1 with primary aromatic amines. Two representative compounds (10, 11) were also synthesized by reacting aqua-triphenylstannyl 2-formylbenzoate [PhSn(L)(HO)] (9) with aniline and p-fluoroaniline, respectively. These compounds were characterized by elemental analysis, IR and H,C and Sn NMR spectroscopy, as well as single-crystal X-ray diffraction for compounds 5, 7-11 and three pro-ligands. The in vitro cytotoxic activities of 1-11 were assessed using the MTT tetrazolium dye assay against HeLa (human cervical) and MDA-MB-231 (breast) cancer cells, with IC values revealing high activity. Compared to cisplatin, compounds 1-11 exhibited enhanced cytotoxic efficacy, indicating their potential as potent anticancer agents. Among these, 1 and 5 demonstrated maximum inhibition in HeLa cells, with negligible effect on normal human embryonic kidney (HEK) cells. The combined results of the DCFH-DA dye and Hoechst 33342/PI nuclear staining assays, along with flow cytometry analysis, show that they possess a dual mode of action: They induced apoptotic cell death, attributable to the tin-assisted generation of reactive oxygen species. Cell cycle analyses indicated that compounds 1 and 5 exhibit cell growth inhibition and may cause turbulences in the G1 and G2/M phases.
A series of pale yellow imine-functionalized acetyloxy(4-(arylideneamino)phenyl)mercury(II) compounds (2-7) were obtained by the reactions of acetyloxy(4-aminophenyl)mercury(II) (1) with arylaldehydes in equimolar ratios in absolute ethanol under reflux conditions. Organomercury compounds 2-5 and 7, when treated with 1,5-diphenylthiocarbazone (dptc) in chloroform, formed dark-red (4-((E)-arylideneamino)phenyl)(((Z)-((E)-phenyldiazenyl) (2-phenylhydrazono)methyl)thio)mercury compounds (8e12) in alkaline medium. The reaction of 7 with a slight excess of mercuric chloride in anhydrous methanol led to the formation of the bimetallic compound (2-[4-(acetyloxymercuryl) This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
M A N U S C R I P T A C C E P T E D ACCEPTED MANUSCRIPT[ Construction of mono-and a bi-metallic organomercury/mercury and organomercury/cadmium compounds were accomplished from an enzyme activator via suitably designed imine-functionalized organomercury ligand.
M A N U S C R I P T A C C E P T E D ACCEPTED MANUSCRIPT
A two-dimensional homobimetallic mercury coordination polymer (2-[4-(acetyloxymercuryl)phenyl]imi nomethylpyridine-j2N,N0)dithiocyanatomercury(II) (1) was synthesized and characterized by FT-IR, 1H-NMR spectroscopic and single crystal X-ray diffraction techniques. Crystallographic results reveal that the primary structural building unit in the structure is a centrosymmetric tetranuclear entity where long Hg-N bonds link a thiocyanate ligand of the dinuclear asymmetric unit to the acetate coordinated Hgatom of its neighbor. These tetranuclear units are then linked into extended chains and the chains are cross-linked by weaker interactions to give a two-dimensional polymeric structure.
The title dimethyl sulfoxide solvate, [Hg2(C12H9ClN2)I2]·C2H6OS, features tetrahedrally and linearly coordinated HgII atoms. The distorted tetrahedral coordination sphere is defined by chelating N atoms that define an acute angle [69.6 (3)°] and two I atoms that form a wide angle [142.80 (4)°]. The linearly coordinated HgII atom [177.0 (4)°] exists with a donor set defined by C and Cl atoms. Secondary interactions are apparent in the crystal packing with the tetrahedrally and linearly coordinated HgII atoms expanding their coordination environments by forming weak Hg⋯I [3.772 (7) Å] and Hg⋯O [2.921 (12) Å] interactions, respectively. Mercury-containing molecules stack along the a axis, are connected by π–π interactions [inter-centroid distance between pyridine and benzene rings = 3.772 (7) Å] and define channels in which the dimethyl sulfoxide molecules reside. The latter are connected by the aforementioned Hg⋯O interactions as well as C—H⋯I and C—H⋯O interactions, resulting in a three-dimensional architecture.
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