Tumor necrosis factor-α induced protein 8 (TNFAIP8/TIPE) family is differentially expressed in oral cancer and regulates tumorigenesis through Akt/mTOR/STAT3 signaling cascade

Monisha, Javadi; Bordoloi, Devivasha; Banik, Kishore; Roy, Nand Kishor; Girisa, Sosmitha; Singh, Anuj Kumar; Longkumer, Imliwati; Baruah, Munindra Narayan; Kunnumakkara, Ajaikumar B.

doi:10.1016/j.lfs.2021.120118

Cited by 10 publications

(2 citation statements)

References 79 publications

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“…The knockdown of TIPE2 suppressed AKT and mTOR expression and activation, and because AKT and mTOR have activating effects on NF-κB and STAT3, the levels of p-STAT3 and p-NF-κB would be consequently reduced, finally leading to a decrease in proliferation and migration. The knockdown of TIPE3 significantly decreases the levels of mTOR and p-mTOR as well, but different from other family members, the knockdown of TIPE3 failed to change the level of p-AKT, suggesting that its regulation may be through activation of the mTOR/STAT3 pathway (Padmavathi et al, 2021;Bordoloi et al, 2020).…”

Section: Stat3mentioning

confidence: 87%

How is the AKT/mTOR pathway involved in cell migration and invasion?

XU¹,

HAO²,

HAN³

et al. 2023

Biocell

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As a pathway that plays a role in nutrient absorption, anabolic response, cell growth and survival, the important role of AKT/mTOR in tumorigenesis has also come to light. For cancer patients, most deaths are caused by the growth of metastatic tumors outside the primary focus. Therefore, migration and invasion in the late stage of tumor progression are the main unresolved issues in the study of tumor pathogenesis, and AKT/mTOR has been found to participate in the migration and invasion of cancer cells, which means that the study of this pathway may contribute to a solution for the problem. Because of its extensive and complex functions in the organism, this pathway can be regulated by a variety of different signals in the body, and then realize its function through different downstream signal molecules. This article reviews the proteins that can indirectly affect this pathway by regulating the common upstream signaling molecules of this pathway, and the proteins that can directly affect the level of phosphorylation of AKT/mTOR in cancer cells. We also review the proteins that can co-regulate this pathway and its downstream pathways. Through this study, we hope to gain a deeper understanding of the regulatory mechanism of the AKT/mTOR pathway in cancer cells, in hopes of finding effective and harmless cancer treatment targets in the future.

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Section: Stat3mentioning

confidence: 87%

How is the AKT/mTOR pathway involved in cell migration and invasion?

XU¹,

HAO²,

HAN³

et al. 2023

Biocell

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show abstract

“…TNFAIP8L1 regulated oral cancer progression through Akt/mTOR signaling pathway. [ 51 ] In colon cancer, TNFAIP8L1 was downregulated in cancer tissues and positively associated with prognosis of colon cancer patients. TNFAIP8L1 regulated colon cancer progression by directly targeting β-catenin.…”

Section: Discussionmentioning

confidence: 99%

A pan-cancer analysis of TNFAIP8L1 in human tumors

Sun,

Zhang,

Zhu

et al. 2023

Medicine

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TNFAIP8L1, as a recently identified member in TNFAIP8 family, plays an important role in tumorigenesis. However, a pan-cancer analysis of TNFAIP8L1 in human tumors has not been conducted until now. The main purpose of study is to investigate TNFAIP8L1 during 33 different types of human tumors by using TCGA and GTEx. The pan-cancer analysis showed that TNFAIP8L1 was significantly over-expressed in 15 cancers and low-expressed in 9 cancers. There were distinct relations between TNFAIP8L1 expression and prognosis of patients with cancer. Furthermore, we also found that DNA methylation and RNA modification of TNFAIP8L1 were associated with many cancers. And then, we detected that TNFAIP8L1 level was positively associated with cancer-associated fibroblasts (CAFs) in many tumors. And, we obtained that TNFAIP8L1 expression was related with most of immune inhibitory and stimulatory genes in multiple types of tumors. We also found TNFAIP8L1 expression was correlated with most of chemokine, receptor, MHC, immunoinhibitor and immunostimulator gens in most of cancers. Moreover, we detected TNFAIP8L1 expression was associated with TMB and MSI in several tumors. Finally, TNFAIP8L1 gene had a significant positive association with 5 genes including BCL6B, DLL4, PCDH12, COL4A1 and DLL4 in the majority of tumors. GO enrichment and KEGG pathway analyses showed that TNFAIP8L1 in thepathogenesis of cancer may be related to “purine nucleoside binding,” “purine ribonucleoside binding,” “ECM-receptor interaction,” etc. Our first pan-cancer study may provide a deep comprehending of TNFAIP8L1 in tumoeigenesis from different tumors.

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The Inhibitory Mechanisms of Capsaicin Against Colorectal Cancer

Sadik,

Pandurangan

2024

Capsaicinoids

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Tumor necrosis factor-α induced protein 8 (TNFAIP8/TIPE) family is differentially expressed in oral cancer and regulates tumorigenesis through Akt/mTOR/STAT3 signaling cascade

Cited by 10 publications

References 79 publications

How is the AKT/mTOR pathway involved in cell migration and invasion?

How is the AKT/mTOR pathway involved in cell migration and invasion?

A pan-cancer analysis of TNFAIP8L1 in human tumors

The Inhibitory Mechanisms of Capsaicin Against Colorectal Cancer

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