2021
DOI: 10.1016/j.lfs.2021.120118
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Tumor necrosis factor-α induced protein 8 (TNFAIP8/TIPE) family is differentially expressed in oral cancer and regulates tumorigenesis through Akt/mTOR/STAT3 signaling cascade

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Cited by 10 publications
(2 citation statements)
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“…The knockdown of TIPE2 suppressed AKT and mTOR expression and activation, and because AKT and mTOR have activating effects on NF-κB and STAT3, the levels of p-STAT3 and p-NF-κB would be consequently reduced, finally leading to a decrease in proliferation and migration. The knockdown of TIPE3 significantly decreases the levels of mTOR and p-mTOR as well, but different from other family members, the knockdown of TIPE3 failed to change the level of p-AKT, suggesting that its regulation may be through activation of the mTOR/STAT3 pathway (Padmavathi et al, 2021;Bordoloi et al, 2020).…”
Section: Stat3mentioning
confidence: 87%
“…The knockdown of TIPE2 suppressed AKT and mTOR expression and activation, and because AKT and mTOR have activating effects on NF-κB and STAT3, the levels of p-STAT3 and p-NF-κB would be consequently reduced, finally leading to a decrease in proliferation and migration. The knockdown of TIPE3 significantly decreases the levels of mTOR and p-mTOR as well, but different from other family members, the knockdown of TIPE3 failed to change the level of p-AKT, suggesting that its regulation may be through activation of the mTOR/STAT3 pathway (Padmavathi et al, 2021;Bordoloi et al, 2020).…”
Section: Stat3mentioning
confidence: 87%
“…TNFAIP8L1 regulated oral cancer progression through Akt/mTOR signaling pathway. [ 51 ] In colon cancer, TNFAIP8L1 was downregulated in cancer tissues and positively associated with prognosis of colon cancer patients. TNFAIP8L1 regulated colon cancer progression by directly targeting β-catenin.…”
Section: Discussionmentioning
confidence: 99%