GER and atopy should be investigated in patients with recurrent spasmodic croup. Recurrent croup is a non-specific manifestation of atopy. Patients with atopy should be followed closely for developing bronchial asthma.

The aim of this research was to compare the protective effects of mesna, hyperbaric oxygenation (HBO), and their combination in cyclophosphamide-induced hemorrhagic cystitis in guinea pigs. Following one dose of i.p. 21.5 mg./kg. mesna administration 20 minutes before i.p. 68.1 mg./kg. cyclophosphamide, 3 additional doses of mesna were given every three hours. A total of 8 HBO exposures, 5 of which were applied prophylactically before cyclophosphamide, were performed at 2.8 ATA for 90 minutes 2 times a day. Although mesna or HBO provided significant protection for cyclophosphamide-cystitis in animal bladders, there was also significant damage compared with controls. The combination of mesna and HBO, which act through independent mechanisms, resulted in complete protection, since mean histological scores and hematuria levels in this group were not different from controls (p >0.05). Therefore, this combination may be a useful tool in the prophylaxis and treatment of cyclophosphamide-induced hemorrhagic cystitis.

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The objective of this study was to investigate the effects of hydrolyzed and live forms of yeast products from Saccharomyces cerevisiae on in vitro fermentation of a 50:50 forage:concentrate substrate using the rumen simulation technique (Rusitec). The Rusitec system consisted of nine fermentation vessels: three of them received daily 0.5 g/L hydrolyzed yeast, three vessels received daily 0.5 g/L live yeast, and three vessels received no additives (control). After an adaptation period of 7 days, the main fermentation characteristics were evaluated for 7 consecutive days. Ruminal pH was decreased (P < 0.05) by hydrolyzed yeast, whereas no effects were observed after live yeast treatment. Both hydrolyzed and live yeasts tended to increase butyrate production (P = 0.052). Acetate to propionate ratio was significantly higher (P < 0.05) for live yeast. Both products increased NH 3 -N concentration, and it was significantly higher (P < 0.05) in live yeast in comparison with that in hydrolyzed yeast. Digestibility of dry matter was not significantly affected by both yeast treatments. Overall, these results showed that different types of yeast products in terms of their viability status had significant actions in ruminal microbial metabolism in different ways.

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This study was performed to investigate the effects of alfuzosin, doxazosin and tamsulosin in vitro on trigone smooth muscle of rabbit. In this study, fifteen rabbits weighing 2.5 -3 kg were used. One strip in the shape of a trigone was prepared for each of the isolated bladders. Firstly, an initial tension of 1 g was placed on each segment, and we waited for equilibration by constantly bubbling with 95% O 2 and 5% CO 2 . Next, the determination level of electrical stimulation which created submaximal contraction and effective dosage were found for trigone and they were determined by applying different concentrations of phenylephrine (10

Summary:Ionophore antibiotics in sub-therapeutic doses have been used since 1970s to improve ruminal fermentation. But use of antibiotics as feed additives was banned in the European Union and Turkey in 2006 since they leave residues in animal products and develop resistance in bacteria. This has shifted the focus of the studies to safer alternatives such as plant extracts and their secondary metabolites to alter ruminal fermentation in order to improve ruminant productivity. In this review, general and recent knowledge about plant extracts and plant secondary metabolites as modifiers of ruminal fermentation are summarized. Furthermore, potential efficacies and possible disadvantages of these substances are also discussed.Keywords: Plant extracts, plant secondary metabolites, rumen fermentation.