Relaxation Responses of Trigonal Smooth Muscle from Rabbit by Alpha1-Adrenoceptor Antagonists Alfuzosin, Doxazosin and Tamsulosin

Karadeniz, Ali; Pişkin, İlksin; Eşsiz, Dinç; Altıntaş, Levent

doi:10.2754/avb200877010081

Cited by 4 publications

(4 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Exposure of liver to some chemicals or drugs leads to morphological changes and in turn affects homeostatic balance of many processes (Arika et al, 2016). Drug induced hepatic injury have become a major hurdle to pharmaceutical industry leading drug development termination, post-market withdrawal and many more (Karadeniz et al, 2008;Sharif et al, 2013;Abubakar et al, 2015;Arika et al, 2016;Odusanya et al, 2017;Enroth et al, 2018;Kaplan, 2019).…”

Section: Histopathology Analysis Of and Livers At 6 Th And 8 Th Weeksmentioning

confidence: 99%

Body Weight Determination and Histological Examination of Livers in Normal Rats Administered with Tamsulosin

Dikko¹,

Sarkingobir²

2020

jasem

View full text Add to dashboard Cite

The objective of this study was to investigate histopathology of livers and carry out body weight determination in normal rats administered with tamsulosin. Standard methods and procedures were used in this study. The results were revealed. Pertaining weight, at the 3rd , 6th and 8th weeks of the study, no significant difference (P>0.05) in weight was found in the group of rats treated with carvedilol (positive control), tamsulosin low dose (12μg/kg) and high dose tamsulosin (40μg/kg) compared to normal control group, respectively. Other inter-groups comparisons were not significantly different, respectively. Pertaining liver morphology, liver sections of groups revealed no significant histological lesions compared to the normal control group at the 6th and 8th weeks of the study, respectively. This study revealed that the tamsulosin cause no histopathological lesion, thus the drug might be safe to the liver and its biochemical processes. Keywords: Tamsulosin, Liver, histopathology, weight, Wistar rats

show abstract

Section: Histopathology Analysis Of and Livers At 6 Th And 8 Th Weeksmentioning

confidence: 99%

Body Weight Determination and Histological Examination of Livers in Normal Rats Administered with Tamsulosin

Dikko¹,

Sarkingobir²

2020

jasem

View full text Add to dashboard Cite

show abstract

“…Some researchers showed that the in vivo contractions of dog [19], and invitro contraction of rat [20], the smooth muscle of prostate induced by epinephrine and phenylephrine are inhibited by tamsulosin. Moreover, the contractions resulted by phenylephrine in the human prostate smooth muscle are blocked by increasing the concentration of tamsulosin, others mentioned that the contractions by phenylephrine in the dog bladder prevented by tamsulosin competitively [21].…”

Section: The Vasorelaxant Effect Of Tamsulosin On Isolated Renal Artementioning

confidence: 99%

“…Also Troxel, et al [22], found that the addition of tamsulosin blocks the stimulatory effect of phenylephrine. Previously mentioned that, contractions of the rat tail [23], and mesenteric artery [24], induced by phenylephrine or noradrenalin were semi completely prevented by tamsulosin as compared to the effects of other alpha-adrenergic antagonists, such as prazosin, phentolamine, and tamsulosin hydrochloride may cause facilitate flow of urine by inhibition of alpha-adrenergic receptors in diverse species [21]. The result of the current study regarding the renal artery supports the previous findings for the contraction inhibitory of tamsulosin in other tissues; this may be due to the presence of the receptors in the renal artery.…”

Section: The Vasorelaxant Effect Of Tamsulosin On Isolated Renal Artementioning

confidence: 99%

The relaxant effect of Tamsulosin in the vascular reactivity of goat isolated renal artery

Asaad

Kakey

2019

KJAR

View full text Add to dashboard Cite

Alpha-blockers including tamsulosin, are medications that relax muscles in the urinary tract to facilitate stone passage into the bladder. This research aimed to investigate the possible action of tamsulosin (1 × 10 -3 -10 -8 M), in the vascular reactivity of goat isolated renal artery by using the organ bath and PowerLab data acquisition system. The results of recording and analysing showed that tamsulosin caused a concentrated-dependent relaxation of endothelium intact renal artery rings precontracted with a high level of KCl (60 mM) or phenylephrine (PE) (10 -5 M), also tamsulosin exhibited potent inhibitory effects on PE, and less potent on KCl-induced contractions. Renal artery rings preincubated with potassium (K + ) channels blocker glibenclamide (GLIB), 4-aminopyridine (4-AP), prostaglandin I2 (PGI2) inhibitor (indomethacin) and epoxyeicosatrienoic acid (EET) inhibitor (Clotrimazole) have a significant effect in relaxation induced by tamsulosin. On the other side, subtype blockers from other K + channels (tetraethylammonium, TEA), barium chloride (BaCl2) and inhibitor of nitric oxide (NO) synthase (L-Name) not exhibited any role in the relaxation effect of tamsulosin. Furthermore, the role of L-type of calcium channels (nifedipine) and tamsulosin, suggesting a Ca ++ channel blocking mechanism has a relaxant effect in the urinary tract smooth muscles. Thus, from these results, it can be concluded that both potassium and calcium channels play an important role in relaxation effect of tamsulosin, which is mediated possibly through blocking of KV, KATP, PGI2, EET and voltage-dependent calcium channels.

show abstract

“…Multiples studies prove that a adrenoreceptors blocker plays an important role in treating acute urinary retention in case of benign prostatic hyperplasia (BPH) [12][13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Doxazosin Effect on Neurogenic Bladder with Urine Retention in Female Dogs

et al. 2021

View full text Add to dashboard Cite

This short communication describes the effect of Doxazosin in case of urinary retention in female dogs due to motor neuron lesions produced by spinal trauma or spinal compression consecutively to intervertebral disk degeneration and extrusion. The study aims to determine whether the treatment of urinary retention in case of neurogenic bladder in female dogs, using 1 adrenergic blocker is effective in spontaneous recovery of the examined patients. Ten female dogs presenting with urinary retention were examined in the laboratory of Radiology, Faculty of Veterinary Medicine Cluj Napoca. The patients were examined using CT, radiography and ultrasonography in order to identify the spinal cord injury that is responsible for neurogenic bladder. The dose of Doxazosin used in treatment of voiding problem in neurogenic bladder was 1mg/kg, single dose per day. Depending on the spinal cord compression cause, the urine retention symptom was resolved.

show abstract

Relaxation Responses of Trigonal Smooth Muscle from Rabbit by Alpha1-Adrenoceptor Antagonists Alfuzosin, Doxazosin and Tamsulosin

Cited by 4 publications

References 32 publications

Body Weight Determination and Histological Examination of Livers in Normal Rats Administered with Tamsulosin

Body Weight Determination and Histological Examination of Livers in Normal Rats Administered with Tamsulosin

The relaxant effect of Tamsulosin in the vascular reactivity of goat isolated renal artery

Doxazosin Effect on Neurogenic Bladder with Urine Retention in Female Dogs

Contact Info

Product

Resources

About