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Potential negative effects of exposure to Nigerian Qua Iboe Brent crude oil on the reproductive system of male rats was investigated. Forty Sprague-Dawley rats were used for the experiment. Exposure to Nigerian Qua Iboe Brent crude oil was achieved via oral administration of increasing doses (0.1, 0.2, and 0.4 ml/rat) every other day for 4 weeks. Cauda epididymal sperm reserves and relative weights of the testes as well as histological features of the testes of rats that received the crude oil treatment were compared to those of control rats. The results described here showed a significant (p < 0.01) dose-dependent reduction in the cauda epididymal sperm reserves of rats that received crude oil treatment relative to the control group. The morphology of testes of the crude oil-exposed rats was characterized by the presence of interstitial exudates, degeneration, and necrosis of spermatogenic and interstitial (Leydig) cells. Findings indicate that exposure of male rats to Nigerian Qua Iboe Brent crude oil may have adversely affected their reproductive systems. This may imply possible reproductive health hazards for animals and humans that may be exposed to this environmental pollutant, especially in areas where oil spillage is a common feature.

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This experiment stands to conclude that combination of 125 mg/kg bw extract and 7 mg/kg bw DDA is very effective in the treatment of trypanosomosis, caused by T. brucei. This combination therapy proved to be better than single therapy of DDA.

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Aim:To evaluate the effects of graded doses of ethanolic stem bark extract of Picralima nitida on haematological profile, some serum reproductive hormones, sperm reserves and testicular histomorphology of male albino rats. Study Design: Thirty male albino rats, weighing between 120 and 200 grams were randomly assigned into six groups of five rats each. Group A received 0.5 ml of distilled water (normal control). Groups B, C and D received 100, 200 and 400 mg/kg BW of the extract respectively. Group E received 2.5 mg/kg BW of CdCl 2 (negative control), while Group F received 5 mg/kg BW of Sildenafil (positive control); orally every other day for six weeks. Place and Duration of Study: Methodology: At the end of the experiment, blood samples were collected for haematology and Mbegbu et al.; JAMPS, 14(1): 1-14, 2017; Article no.JAMPS.34359 2 serology, whereas testicular sections were collected for histopathology following the standards procedures. Data obtained were analyzed by One-way ANOVA. Results: The result showed that all doses of the extract increased neutrophil count, but decreased (P < 0.05) monocyte and RBC counts; 200 and 400 mg/kg BW of the extract decreased (P < 0.05) PCV values; and only 400 mg/kg of the extract reduced (P < 0.05) HB values. 200 and 400 mg/kg BW of the extract, and 2.5 mg/kg BW of CdCl 2 decreased (P < 0.05) serum testosterone and sperm counts. The normal control, 100 mg/kg BW of the extract and 5 mg/kg BW of Sildenafil had normal testicular histoarchitecture; whereas 200 and 400 mg/kg BW of the extract, and 2.5 mg/kg BW of CdCl 2 had slight, moderate and severe degeneration of the germinal epithelium and interstitium, with depletion of sperm cells in the lumen of the seminiferous tubules respectively. Conclusion: This study revealed that treatment with ethanolic stem bark extract of Picralima nitida above 100 mg/kg BW adversely affected haematological and reproductive parameters in male albino rats. Original Research Article