Background: Laparoscopy induces adhesion due to ischemia-reperfusion injury. However, the detail pathomechanism is poorly understood. This study aimed to investigate the impact of laparoscopy on mast cell and mesothelium morphological changes in the rat. Methods: Forty-nine males of Sprague-Dawley Rattus norvegicus were divided into four groups: a) control and b) intervention groups P1, P2, and P3 that underwent 60 min laparoscopic using carbon dioxide (CO 2) insufflation at 8, 10, and 12 mmHg groups, respectively. Serum hydrogen peroxide (H 2 O 2), catalase (CAT), superoxide dismutase (SOD), malondialdehyde (MDA), and oxidative stress index (OSI) levels were determined 24 h after laparoscopy. Histopathological analyses of mast cell infiltration and degranulation and mesothelium thickness in the liver, greater omentum, mesenterium, small intestine, and peritoneum were performed 7 days after the procedure. Results: H 2 O 2 , MDA, and OSI levels were significantly increased in the intervention groups compared with the control (p<0.05), while the SOD and CAT levels were decreased in the intervention groups compared with the control (p<0.05). Mast cell infiltration and degranulation were higher in the intervention groups than in control (p< 0.05), while the mesothelium thickness was significantly lower in the laparoscopic groups than in control (p<0.05). Interestingly, the decrease in mesothelium thickness was strongly associated with the increase in mast cell infiltration and degranulation (p<0.01). Conclusions: Our study shows that laparoscopy in rats increases mast cell infiltration and degranulation, which also results in and correlates with a decrease in mesothelial thickness.
Objective: Aim of this study is to describe the oral mucosa condition of shisha user. A preliminary observasional study was conducted at several sisha cafe at South Jakarta. Under informed consent, subject with habit of tobacco and shisha smoker were included. Material and Methods: Shisha is a water pipe that contains tobacco extract and flavored.It is burnt using coal. It produces the smoke through the vessel and inhaled using a hose which gives good aroma. The culture of shisha smoking is popular in Midle East country that curently has been also entering Indonesia. Results: The side effect of shisha smoking habit is still very rarely reported. Sociodemographic data (age, gender, durationand frequency of smoking), salivary flow rate and oral mucosa changes were documented. Eighteen subjects were recruited into this study. Most of shisha smoker was also tobacco smoker. Shisha was more practiced by males at age (15-24 years old). The oral mucosa changes such as keratosis, melanosis, leukoedema, coated tongue, gingivitis and xerostomia were found on subject with habit of tobacco smoking or both shisha and tobacco smoking. Conclusion: Apparently the shisha smoking habit may casue oral mucosa changes almost the same with tobacco smoking habit.
Kebudayaan adalah sebuah sistem masyarakat yang meliputi suatu keseluruhan cara hidup manusia dalam kelompoknya yang berupa kebudaayaan fisik maupun nonfisik dan bersifat turun-temurun melalui proses belajar sehingga menjadi bagian dari kehidupan. Budaya genteng merupakan kebudayaan yang dimiliki masyarakat Mayongkidul jepara. Genteng merupakan sebuah kerajinan dari tanah liat yang dibakar menggunakan suhu tinggi dan digunakan sebagai atap bangunan. Dalam pembuatannya tercermin nilai-nilai karakter yang teah melekat pada masyarakat pengrajin di desa Mayongkidul. Dalam konteks sekarang ini karakter anak di indonesia dapat dikatakan minim moralitas. Hal ini dapat dilihat dari berita yang muncul diberbagai media salah satunya adalah dan kenakalan remaja. Pendidikan karakter sudah menjadi program pemerintah yang bertujuan membentuk individu-individu yang bermoral akan tetapi tampakanya belum berjalan dengan sempurna. Maka dibutuhkan kerjasama antara pendidikan, masyarakat dan keluarga. Penelitian ini bertujuan untuk menggambarkan nilai-nilai pendidikan karakter dalam budaya genteng. Penelitian ini menggunakan metode kualitatif naratif dalam penyajian data hasil penelitiannya. Proses pengumpulan datanya melaui wawancara, observasi serta catatan lapangan. Hasil penelitian menunjukan dalam budaya genteng terdapat nila-nilai pendidikan dalam menumbuhkan karakter antara disiplin, kerjasama, bertanggung jawab dan jujur. Oleh karena itu harus di lestarikan agar tidak tergerus oleh perkembangan zaman.
Haruan is Kalimantan’s indigenous fish which has the potency to accelerate wound healing. Haruan extract hassubstantial properties such as albumin, Zn,Cu, and Feto accelerate wound healing. The purpose of this study is to assessthe effect of haruan extract on wistar rats buccal mucosa wound healing on day 1, 3, 5, and 7 histopathologically. Thisstudy was purely experimental with pretest-posttest with control group design. Samples were divided into 4 treatmentgroups, haruan extract 25%, 50%, 100% treatment groups and aquadest treatment group as negative control, eachtreatment wasperformed for 7 days. Neocapillariescount reached its peak on day 5. Mean neocapillaries scoring of eachgroup was 12, 16.5, 18.5, 6 respectively. Two way Anova and post hoc LSD tests presented a significant differencebetween negative control and haruan extract groups. In conclusion, haruan extract treatment significantly increasedneocapillaries count in wound healing process.
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