The primary structure of a gene of the Na +,K+-ATPase multigenic family in the human genome has been determined. The gene corresponds to a hypothetical ~dlI-form of the enzyme catalytic subunit. The gene comprises over 25000 bp, and its protein coding region includes 23 exons and 22 introns. Possible correlation between structural features of the protein and location ofintrons in the gene are discussed.
Five different nucleotide sequences have been found in the human genome homologous to the gene of the α‐subunit of Na+,K+‐ATPase. A comparative analysis of the primary structure of these genes in the region 749–1328 (in coordinates of cDNA from the pig α‐subunit) is presented.
The primary structure of the putative regulatory region of a gene of the Na+,K+-ATPase multigene family in the human genome has been determined. This region includes the first exon with all of the untranslatable sequence of mRNA and a dozen nucleotides, coding for the first four amino acids of the hypothetic precursor of the a+-subunit. The entire region comprises over 1400 bp. The possible role of specific nucleotide blocks within this region in comparison with other genes is discussed.
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