BACKGROUND: Immune system and inflammatory response play an essential role in the development of secondary brain injury (SBI) after traumatic brain injury (TBI). An inflammatory biomarker that can reflect the SBI severity is needed to increase the effectivity of TBI management and prevent morbidity and mortality post-TBI. Neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR), which are more affordable than C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR), theoretically have the potential to be used as a marker of the SBI severity. However, NLR and PLR in daily medical practice are not yet fully utilized. AIM: The aim of the study was to correlate NLR and PLR with CRP and ESR as a marker of SBI severity post-TBI. METHODS: This cross-sectional study was conducted at Sanglah Hospital Denpasar from January to April 2020. Patients diagnosed with TBI were included in this study by consecutive sampling. The blood samples were taken at 24-h post-TBI to obtain the NLR, PLR, CRP, and ESR results. Spearman’s correlation test was conducted to determine the correlation between NLR and PLR with CRP and ESR. RESULTS: Eighty-five patients were included in data analysis. Median ± (interquartile range) of the NLR, PLR, CRP, and ESR were 7.60 ± (6.83), 145.58 ± (76.95), 60.83 ± (66.3), and 12.50 ± (13.85) consecutively. NLR and PLR had a significant positive correlation with CRP (r = 0.472, **p < 0.01; r = 0.283, **p < 0.01 consecutively). But, NLR and PLR were not correlated with ESR. CONCLUSION: NLR and PLR can become a useful and more affordable marker for reflecting the SBI severity in acute TBI.

BACKGROUND: Single-nucleotide polymorphism in the stromal cell-derived factor-1 (SDF-1)/CXCL12 gene had been associated with an increased risk of coronary artery disease (CAD). However, several published studies have shown inconsistent results. AIM: A meta-analysis was assessed to evaluate the association between SDF-1 3’A-gene polymorphism and CAD in the literature. METHODS: A systematic review was conducted in accordance with PRISMA guidelines and adhering to the Cochrane Handbook for Systematic Reviews. The literature search strategy was carried out on April 3, 2019, from PubMed, EBSCO, Google Scholar, and DOAJ during 2013–2018 period using various keywords related to SDF-1, CXCL12, polymorphism, and CAD. Original data from the group, case-control study, English full-text, and DNA polymorphism assessment using polymerase chain reaction were enrolled. Gene polymorphism in A-base nucleotide among patients with CAD and healthy subjects were evaluated. All data were analyzed using Review Manager 5.3 (Cochrane, Denmark) for meta-analysis. RESULTS: Five eligible studies extracted for data analysis (2013–2018) based on the assessment of 2-independent reviewers. Several studies have been excluded due to irrelevant criteria evaluated. A significant result was found between SDF-1 3’A gene polymorphism with the increased risk of CAD in the overall effect evaluation using a fixed-effects model (odds ratio [OR]: 2.02; 95% confidence interval 1.54-2.65; I2: 34%; p<0.001) on the forest plot. CONCLUSION: Our meta-analysis suggests that gene polymorphism in A-base nucleotide of SDF-1/CXCL-12 was associated with the susceptibility of CAD. However, a bigger-scale and well-design of case-control study should be conducted to clarify these conclusions.

The activity of traditional dodol stirrer workers is done with standing position. The stirring process is done monotonically and over a long period of 5 hours. This study aims to show that workplace stretching exercise administration and modification of working conditions may decrease musculoskeletal and fatigue complaintas in traditional dodol stirrer workers. The stirring tool (siut) used by the worker does not correspond to anthropomethry, causing a work with a bent position. This study was an experimental study, with the same subject design. Period I subjects were treated with conventional working condition. Period II subjects were treated with workplace stretching exercise administration and improved working conditions in the form of re-design the stirring tool(siut) of the dodol stirrer and active rest. Musculoskeletal complaints were measured by Nordic body map questionnaires on a 4 likert scale, working fatigue using 30 item rating scales. Analysis of the collected data is started with the descriptive analysis and the normality data tested using Shapiro-Wilk. Further, the data that has normal distribution are analyzed using t-paired and the data that has not a normal distribution are analyzed using Wilcoxon test. This study indicated that the administration of workplace stretching exercise and modification of working conditions can decreasing musculoskeletal decline of 18.3 % from the mean 12.67±0.50 to 5.59±0.52 and fatigue decreased by 18.5% from the mean 12.42±1.45 to 5.34±0.66 It can be concluded that the provision of workplace stretching exercise and modification of working condition can decrease musculoskeletal complaintas and fatigue of dodol stirrer workers. So it is advisable for the dodol making industry to applied this technique of exercise to minimize complaints due to the working process of stirring dodol.

Pendahuluan: Kondisi fisik merupakan salah satu faktor penting yang harus dimiliki oleh setiap pemain dalam upaya pencapaian prestasi maksimal. Kemampuan kondisi fisik yang baik ditandai dengan pemain memiliki VO2max yang baik. VO2max merupakan nilai tertinggi dimana seseorang dapat mengkonsumsi oksigen selama latihan. VO2max dapat ditingkatkan dengan latihan fisik seperti latihan fartlek dan continous running.  Tujuan penelitian ini adalah untuk mengetahui perbedaan latihan fartlek dan continous running dalam meningkatkan VO2max pada siswa ekstrakurikuler bola voli MAN 2 Manggarai. Metode: Penelitian ini adalah penelitian eksperimental dengan rancangan Randomized Pre –Post Test Two Group Design. Jumlah sampel penelitian sebanyak 26 orang yang dibagi menjadi dua Kelompok. Kelompok 1 berjumlah 13 orang yang diberi pelatihan fartlek dan Kelompok 2 berjumlah 13 orang yang diberikan pelatihan continous running. Pelatihan ini dilakukan selama enam minggu dengan frekuensi waktu tiga kali setiap minggu. VO2max diukur dengan Multi Fitnes Test (MFT) sebelum dan sesudah perlakuan dan perbedaannya diuji dengan paired sampel t-test dan independent sampel t-test. Hasil: Berdasarkan hasil penelitian rerata sebelum pelatihan Kelompok 1 sebesar 32,14±2,6 ml/kg/menit dan sesudah pelatihan 33,59±3,0 ml/kg/menit (p<0,05). Kelompok 2 sebelum pelatihan sebesar 33,01±2,2 dan setelah pelatihan 34,55±2,6 ml/kg/menit (p<0,05), sehingga dapat dikatakan ada peningkatan VO2max pada ke dua Kelompok setelah diberi perlakuan. Rerata sesudah perlakuan Kelompok 1  sebesar 33,59±3,0 ml/kg/menit dan Kelompok 2 sebesar 34,55±2,6 ml/kg/menit menunjukkan nilai p = 0,623, hal ini berarti Kelompok 1 dan Kelompok 2 tidak berbeda bermakna karena nilai p>0,05. Tidak ada perbedaan pada ke dua Kelompok, hal ini disebabkan karena ke dua Kelompok  diberikan perlakuan dengan takaran yang sama. Simpulan: Latihan fartlek dapat meningkatkan VO2max pada siswa ekstrakurikuler bola voli. Latihan continous running dapat meningkatkan VO2max pada siswa ekstrakurikuler bola voli. Tidak ada perbedaan latihan fartlek dan Latihan continous running dalam meningkatkan VO2max pada siswa ekstrakurikuler bola voli MAN 2 Manggarai.

Background: Overweight or obesity is a global health problem that is significantly rising, and it can reduce a person’s quality of life, and also his family. Several factors could influence the Body Mass Index (BMI) as a simple indicator to assess obesity. This study aims to know the factors-related to the BMI among Senior High School students in Buleleng District, Bali, Indonesia, in 2016.Methods: An analytic cross-sectional study using primary data was conducted through direct anthropometric measurements and questionnaires among 164 students at Buleleng District, Bali, Indonesia, in 2016. A stratified random sampling technique was used to enrol the students in Buleleng District that meet the inclusion and exclusion criteria. Variables assessed in this study were gender, age, BMI, parent’s BMI, level of physical activity, and eating habit. Data were analysed using SPSS version 23 for Windows software with a significance level of 0.05.Results: Females were predominant in this study (54.00%) compared with males (46.00%), followed by age 16 years old (41.00%), average BMI of respondents 31.25 kg/m2, and the average parent’s BMI were 27.25 kg/m2. Bivariate analysis showed there was no significant relationship between physical activity level with student’s BMI (p = 0.330), diet level the student’s BMI (p = 0.550), father’s BMI to the student’s BMI (p = 0.205). However, a significant relationship was found between a mother’s BMI to the student’s BMI (p=0.038) Conclusion: A significant relationship was found between mother’s BMI to the BMI of Senior High Scholl students in Buleleng District, Bali, Indonesia, in 2016. According to the result, special attention and counselling on nutritional status against the senior high school students and parents in Buleleng District are necessarily important. Latar Belakang: Kelebihan berat badan atau obesitas merupakan masalah kesehatan dunia yang memiliki kenaikan secara signifikan, dan dapat mengurangi kualitas hidup seseorang, dan juga keluarganya. Beberapa faktor dapat memengaruhi Indeks Massa Tubuh (IMT) sebagai indikator sederhana untuk menilai obesitas. Penelitian ini bertujuan untuk mengetahui faktor-faktor yang berhubungan dengan BMI di antara siswa SMA di Kabupaten Buleleng, Bali, Indonesia, pada tahun 2016.Metode: Penelitian potong lintang analitik menggunakan data primer dilakukan dengan pengukuran antropometrik dan kuesioner secara langsung terhadap 164 siswa di Kabupaten Buleleng, Bali, Indonesia, pada tahun 2016. Teknik pengambilan sampel acak stratifikasi digunakan untuk melibatkan siswa di Kabupaten Buleleng yang memenuhi kriteria inklusi dan eksklusi. Variabel yang dinilai dalam penelitian ini adalah jenis kelamin, usia, BMI, BMI orang tua, tingkat aktivitas fisik, dan kebiasaan makan. Data dianalisis menggunakan SPSS versi 23 untuk perangkat lunak Windows dengan tingkat kebermaknaan 0,05.Hasil: Jenis kelamin perempuan dominan dalam penelitian ini (54,00%) dibandingkan dengan laki-laki (46,00%), diikuti dengan usia 16 tahun (41,00%), BMI rata-rata responden 31,25 kg/m2, dan BMI orang tua rata-rata sebesar 27,25 kg/m2. Analisis bivariat menunjukkan tidak terdapat hubungan yang bermakna antara tingkat aktivitas fisik dengan BMI siswa (p = 0,330), tingkat diet BMI siswa (p = 0,550), maupun BMI ayah dengan BMI siswa (p = 0,205). Namun, terdapat hubungan yang bermakna ditemukan antara BMI ibu dengan BMI siswa (p = 0,038).Kesimpulan: Hubungan yang bermakna ditemukan antara BMI ibu dengan BMI siswa SMA di Kabupaten Buleleng, Bali, Indonesia, pada tahun 2016. Berdasarkan hasil ini, perhatian khusus dan konseling tentang status gizi terhadap siswa SMA dan orang tua di Kabupaten Buleleng merupakan hal yang penting.

Profesi keperawatan sekarang ini dituntut agar mampu tingkatkan kualitas layanan kesehatan dan bisa memberikan pelayanan kesehatan selama 24 jam. Dalam mewujudkannya rumah sakit menerapkan sistem kerja shift.Sistem kerja shift memiliki dampak bagi kesehatan fisik dan psikis.Tuntutan kerja yang tinggi bagi profesi perawat khususnya perawat Isntalasi Gawat Darurat (IGD) dengan etos kerja yang berpacu pada waktudalam menangani kasus-kasus kegawatdaruratan medis. Hal ini bisa mengakibatkan terjadinya stres kerja. Tujuan penelitian ini adalah melihat gambaran tingkat stres kerja perawat dengan kerja shift di ruang IGD RSUD Karangasem. Penelitian ini bersifat  deskriptif dengan desain cross sectional yang dilaksanakan pada bulan September 2016 hingga September 2017. Sampel dipilih menggunakan total sampling yaitu libatkan seluruh perawat dengan kerja shift di ruang IGD RSUD Karangasem yang berjumlah 31 orang. Pengambilan data dilakukan secara langsung menggunakan instrumen penelitian berupa kuesioner OSI-RTM (Occupational Stress Inventory-Revised Edition). Penelitian ini tunjukkan rata-rata usia responden 28,5 tahun dengan usia maksisum 45 tahun dan usia minimum 22 tahun. 51,6% sampel adalah laki-laki, 61,3% sampel sudah menikah dan 48,4% bekerja selama 6 bulan-3 tahun.  87,1% perawat IGD RSUD Karangasem mengalami tingkat stres kerja sedang. Dapat disimpulkan bahwa gambaran tingkat stres kerja perawat IGD RSUD Karangasem yaitu mayoritas mengalami tingkat stres kerja sedang dengan tingkat stres kerja responden berdasarkan karakteristiknya yaitu terdistribusi merata laki-laki dan perempuan, responden belum menikah alami tingkat stres kerja sedang yang lebih tinggi dan mayoritas responden masa kerja 6 bulan – 3 tahun yang mengalami stres kerja sedang. Kata Kunci: Stres Kerja, Perawat, Kerja Shift, IGD, RSUD

Characteristics of batik stamp is done by standing working attitude. Equipment used in the form of a work desk height is not in accordance with anthropometric causing work attitude with a bent position and in giving patterns on fabrics monotonous and repetitive. Intervention by designing the working conditions such as repair work desk, a picturesque repair work organization in the form of active rest between working time and rest periods as well as preventive measures in the form of Pilates exercise can reduce the complaints caused by work processes. This study aims to show that the administration of Pilates exercise and modification of working conditions can reduce the subjective complaints and improve productivity on a batik cap in batik industry. This Study is Experimental research, with treatment by subject design. The first phase (I) subjects treated with conventional working conditions. The second phase (II) subjects treated with application of Pilates exercise and improvement of working conditions in the form of additional altitude work desk and an active break. Among the second stage, given washing out period and adaptation. Normality test data with ShapiroWilk, paired t-test to test the significance difference variables musculoskeletal disorders, fatigue and work productivity. These results indicate that administration of Pilates exercise and modification of working conditions affect significantly (p <0.05). There was a decrease musculoskeletal 31.6%, 22.1% decrease in fatigue, and increase productivity by 34.56%. The conclusion that the application of Pilates exercise and modification of working conditions can lower subjective complaints and increase the productivity of batik cap in batik industry. So it is advisable to apply to the batik industry, to minimize complaints due process of batik work.

Karakteristik pengukir kendang tambur dilakukan dengan posisi duduk di lantai, sikap kerja membungkuk selama 8 jam dan 6 hari dalam seminggu. Hal inilah yang memicu timbulnya keluhan pegal yang dirasakan terutama pada bagian punggung bawah. Intervensi dengan pemberian alas duduk berupa matras serta upaya preventif   berupa Mc Kenzie exercise dapat mengurangi ketegangan otot erector spinae dan keluhan muskuloskeletal akibat proses kerja. Penelitian ini bertujuan untuk membuktikan bahwa pemberian alas duduk dan Mc Kenzie exercise dapat menurunkan ketegangan otot dan keluhan muskuloskeletal serta meningkatkan produktivitas pada pengukir kendang tambur di UD. Budi Luhur Gianyar.        Penelitian ini merupakan true eksperimental, dengan rancangan sama subjek. Periode 1 subjek diberi perlakuan dengan kondisi kerja konvensional. Periode 2 subjek diberi perlakuan dengan pemberian alas duduk berupa matras dan Mc Kenzie exercise. Di antara ke dua tahap tersebut, diberikan washing out period dan adaptasi. Ketegangan otot erector spinae diukur dengan alat ­Surface Electromyography (SEMG), keluhan muskuloskeletal diukur dengan kuesioner Nordic Body Map dan produktivitas berdasarkan perbandingan antara input dan waktu  dengan output. Efek intervensi dianalisis dengan uji Wilcoxon dan uji T-paired.        Hasil penelitian menunjukkan bahwa terjadi penurunan ketegangan otot erector spinae sebesar 21,39% (p<0,05), penurunan keluhan muskuloskeletal sebesar 29,52% (p<0,05) dan peningkatan produktivitas sebesar 22,13% (p<0,05).        Dapat disimpulkan bahwa pemberian alas duduk dan Mc Kenzie exercise dapat menurunkan ketegangan otot dan keluhan muskuloskeletal serta meningkatkan produktivitas pada pengukir kendang tambur di UD. Budi Luhur Gianyar. Sehingga disarankan untuk diterapkan pada industri pengukir kendang tambur, untuk meminimalkan ketegangan otot dan keluhan muskuloskeletal akibat proses kerja mengukir.