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Cancer stem-like cells (CSC) thought to contribute to head and neck squamous carcinomas (HNSCC) may offer attractive therapeutic targets if a tractable approach can be developed. In this study, we report that silencing c-Met is sufficient to suppress sphere formation, tumor initiation, and metastatic properties of HN-CSC. Pharmacologic inhibition of c-Met with the selective inhibitor PF-2341066 preferentially targeted CSC and synergized with conventional chemotherapy to improve efficacy in a mouse xenograft model of HNSCC, impeding tumor growth and reducing metastasis. Mechanistic investigations showed that CSC elimination was due to downregulation of Wnt/b-catenin signaling in HN-CSC and that the Wnt pathway receptor

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Purpose To analyse outcomes of lacrimal bypass surgery with the Medpor coated tear drainage tube.

This paper presents and compares two permanent magnet vernier (PMV) motors with fractional slot concentrated windings (FSCWs) and integral slot distributed windings (ISDWs). The ISDW PMV motor is newly proposed and optimized for a fair comparison with the existing FSCW one. The equations of back electromotive force of both motors are investigated and derived showing that the ISDW PMV motor has the potential to obtain higher torque capability. Also, their electromagnetic performances, such as torque capability, fault tolerance, loss, and efficiency, are calculated and compared by using the finite-element analysis. Then, the maximum power strategy for PMV motors operating at high speed is presented. The simulated results show that both motors possess excellent flux weakening capability. Finally, the effectiveness of the theoretical analysis is verified by the finiteelement analysis results and experiments on a prototype FSCW PMV motor.

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