No abstract

Glucose oxidase (GOX) can convert glucose into gluconic acid and hydrogen peroxide (HO), which is potentially useful for synergistic cancer-starving and oxidation therapy. Herein we demonstrate a glucose-responsive nanomedicine made of GOX-polymer nanogels to regulate HO production for synergistic melanoma starving and oxidation therapy. GOX-polymer nanogels showed glucose-responsive HO-generating activity in vitro, improved stability, and considerably enhanced tumor retention as compared to native GOX. More importantly, they exhibited high antimelanoma efficacy and no obvious systemic toxicity, whereas native GOX was ineffective and systemically toxic at the same dose. This work paves the way for establishing an endogenous and noninvasive cancer treatment paradigm that is based on intratumoral glucose-responsive, HO-generating chemical reactions.

Porous 1D structured NiS2NP/p-CNF nanohybrids was fabricated by electrospinning, which shows impressive electrochemical performance as anode of Na-ion battery.

Background: Xenobiotics activate nuclear receptor PXR for detoxification and clearance. However, a role of PXR in regulating innate immunity remains unknown. Results: PXR induced NLRP3 expression and triggered inflammasome activation in vascular ECs. Conclusion: PXR plays an important role in the activation of NLRP3 inflammasome in response to xenobiotics. Significance: Our findings revealed a novel mechanism of innate immunity.

No abstract

Our results indicated that Dex could reverse neurodegenerative changes and neuroapoptosis in mice brain of septic mice induced by LPS through anti-inflammatory and antiapoptotic effects.

We first proposed the concept of in situ in vivo bioprinting in order to address the existing deficiencies in conventional bioprinting. Herein we verified this concept taking the case of the treatment for gastric wall injury and presented this work as a preliminary step towards a new method in the field of bioprinting. In this study, a micro bioprinting platform which can be installed to an endoscope was developed to enter the human body and process bioprinting. Printed circuit micro-electro-mechanical-system techniques were used in the design and fabrication of the platform. Control system with high accuracy was developed and performance tests were carried out to verify the feasibility of the platform. The 2-layer tissue scaffolds were printed in a stomach model. Gelatin–alginate hydrogels with human gastric epithelial cells and human gastric smooth muscle cells were used as bioinks to mimic the anatomical structure of a stomach. A 10 d cell culture showed that printed cells remained a high viability and a steady proliferation, which indicated good biological function of cells in printed tissue scaffolds. This work presents an innovative advance not only in the field of bioprinting but also in the clinical sciences.

We proved that miRNA-337 is associated with chondrogenesis through regulating TGFBR2 expression, and miRNA-337 can also influence cartilage-specific gene expression in chondrocytes. These findings may provide an important clue for further research in the arthritis pathogenesis and suggest a new remedy for arthritis treatment.