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Aneurysmal subarachnoid hemorrhage (aSAH), characterized by the extravasation of blood into the subarachnoid space caused by an intracranial aneurysm rupture, may lead to neurocognitive impairments and permanent disability and usually carries poor outcome. Dental or gingiva-derived stem cells have been shown to contribute to immune modulation and neuroregeneration, but the underlying mechanisms are unclear. In the present study, we sought to investigate whether dental pulp stem cells (DPSCs) secrete certain factor(s) that can ameliorate the neural damage and other manifestations in a rat aSAH model. Twenty-four hours after the induction of aSAH, microthrombosis, cortical vasoconstriction, and the decrease in microcirculation and tissue oxygen pressure were detected. Intrathecal administration of DPSC-derived conditioned media (DPSC-CM) ameliorated aSAH-induced vasoconstriction, neuroinflammation, and improved the oxygenation in the injured brain. Rotarod test revealed that the aSAH-induced cognitive and motor impairments were significantly improved by this DPSC-CM administration. Cytokine array indicated the major constituent of DPSC-CM was predominantly insulin growth factor-1 (IGF-1). Immunohistochemistry staining of injured brain tissue revealed the robust increase in Iba1-positive cells that were also ameliorated by DPSC-CM administration. Antibody-mediated neutralization of IGF-1 moderately deteriorated the rescuing effect of DPSC-CM on microcirculation, Iba1-positive cells in the injured brain area, and the cognitive/motor impairments. Taken together, the DPSC-derived secretory factors showed prominent therapeutic potential for aSAH. This therapeutic efficacy may include improvement of microcirculation, alleviation of neuroinflammation, and microglial activation; partially through IGF-1-dependent mechanisms.

A novel LED fishing/working light is proposed to enhance the lighting efficiency of a fishing boat. The study is focused on the freeform secondary lens design so as to create a lamp that attracts fish and sheds light on the deck for the crew's work. The experimental results show that the proposed multisegmented freeform lens can deliver the proposed aim, giving 3 times as much illuminating power as the traditional high-intensity discharge fishing lamp does with the same input of electrical power.

In this study, a light-driving bug zapper is presented for well controlling the diseases brought by insects, such as mosquitoes. In order to have the device efficient to trap the insect pests in off-grid areas, pulse width modulated light emitting diodes (PWM-LED) combined with a solar power module are proposed and implemented. With specific PWM electric signals to drive the LED, it is found that no matter what the ability of catching insects or the consumed power efficiency can be enhanced thus. It is demonstrated that 40% of the UV LED consumed power and 25.9% of the total load power consumption can be saved, and the trapped mosquitoes are about 250% increased when the PWM method is applied in the bug zapper experiments.

A new, highly efficient curved reflex reflector is proposed to meet the requirement of EU ECE (Economic Commission for Europe) regulations based on the commercial design provided by an automotive company which has been in mass production. We used double pins with corner cubes which served as the building element of a SuperPin curved retro-reflector to enhance reflectivity performance. Our experiment outcomes indicated 46% higher retro-reflection efficiency and 33% larger working areas compared with the commercial design.

The study is focused on the asymmetric secondary freeform lens (ASFL) design for creating a low glared light-emitting diode (LED) street light. The lens is mounted on a chip on board (COB) LED as the new LED street light module to perform a non-axial symmetric light intensity distribution. The experimental results show that the street light can work without inclining lamps and reach Chinese National Standards (CNS) and Illuminating Engineering Society of North America (IESNA) standards at the same time.

A highly efficient regular curved retroreflector is proposed to meet the requirements of the US Society of Automotive Engineers (SAE) regulations. It is demonstrated that 28% higher retroreflection efficiency and 33% more working area can be accomplished with the new designed retroreflector when compared with the commercial ones used in modern vehicles.Based on pin-bundling technology, the tooling of a reflex reflector mold can be produced, and it can serve as a testing sample or for mass production. In this study, a reflex reflector sample was designed and produced by bundled metal pins for SAE regulations. A curved retroreflector with new cube-corner structure is proposed and demonstrated. By use of genetic algorithms for optimization, the angles and positions of the pins serve as the optimizing parameters to enhance the performance of a curved retroreflector. Compared with conventional retroreflectors, it is found that 28% higher retroreflection efficiency and 33% more working area can be accomplished with our proposed one. effective working area and reflection efficiency are influenced seriously, and that could lead to the retroreflector not complying with SAE regulations [6,16].Based on pin-bundling technology, the tooling of a reflex reflector mold can be produced, and it can serve as a testing sample or for mass production. In this study, a reflex reflector sample was designed and produced by bundled metal pins for SAE regulations. A curved retroreflector with new cube-corner structure is proposed and demonstrated. By use of genetic algorithms for optimization, the angles and positions of the pins serve as the optimizing parameters to enhance the performance of a curved retroreflector. Compared with conventional retroreflectors, it is found that 28% higher retroreflection efficiency and 33% more working area can be accomplished with our proposed one.

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