Abstract. Gynaecological malignancies contribute significantly to cancer burden and have a higher rate of mortality and morbidity. The aim of this retrospective study was to determine the pattern of gynaecological malignancies identified between January, 2000 and December, 2011, at the Centre for Nuclear Medicine and Radiotherapy (CENAR). At CENAR 5,072 female patients were registered with different malignancies, of which 632 cases were gynaecological malignancies. Ovarian cancer (47%) was the most common gynaecological malignancy, followed by cervical cancer (29%), uterine cancer (14%), vulvar and vaginal cancer (6%), and gestational trophoblastic neoplasm (4%). Of the ovarian cancer cases, 72.5% had epithelial while 26.5% had non-epithelial cancer. Squamous cell carcinoma was 75.9% in cervix and 87.8% in vulva and vagina while endometrial carcinoma (75.9%) was more frequent in uterus. For gestational trophoblastic neoplasm, 69.2% of patients had choriocarcinoma. Ovarian cancer was the most common type for the age range of 50-59 years. In the case of cervical and gestational trophoblastic neoplasm the majority of patients presented at the ages of 40-49 and 30-39 years while uterus, vulvar and vaginal tumor presented in the elderly (>60 years). Thus, ovarian cancer is the leading gynecological malignancy in Pakistan.

Background: Micropapillary carcinoma (MPC), a morphologically distinct subtype of invasive ductal carcinoma, of the male breast is an exceedingly uncommon disease. Case Report: Herein, we report a case of triple-positive MPC of the male breast with axillary lymph node involvement and no recurrence for over 2 years. Specifically, a 60-year-old male patient presented with a hard, elastic, and well-defined painless mass in the right breast. The patient underwent unilateral (right) modified radical mastectomy with axillary clearance. Histopathology revealed MPC grade 3 and metastasis in 16/16 lymph nodes. Hormone receptor analysis demonstrated strong positivity (total score 08) for estrogen/progesterone receptors and overexpression (score 3+) of human epidermal growth factor receptor 2. The patient received adjuvant chemotherapy (6 courses of CAF: cyclophosphamide, doxorubicin, and 5-fluorouracil), radiation, and tamoxifen. The patient has remained disease-free for over 2 years. Conclusion: This study demonstrates that triple-positive MPC of the male breast as a rare malignancy appears to respond promisingly to multimodality treatment.

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In both high- and low-income nations, preterm pre-labou membrane rupture is a significant contributor to perinatal, neonatal, and maternal illness and mortality. Premature membrane rupture puts a woman at risk for postpartum haemorrhage, intraamniotic infection, and even death. The purpose of this study was to ascertain the prevalence of preterm premature rupture of membranes and its related factors among pregnant women admitted to health institutions because little is known about the issue in the study region. A total of 300 participants participated in this research among which 100 had preterm PROM, 100 had PROM, and 100 had preterm deliveries. The ages of the participants ranged from 18-40 years with a mean age of 25.12 ± 4.43 years. Among 300 participants, 9.33, 17.33, 21, 24.33, and 28% were 18-20, 21-25, 26-30, 31-35, and 40 years of age, respectively. Among the total, 19 (6.33%), 271 (90.33%) and 10 (3.33%) were divorced, married and widowed, respectively. Among a total, 44, 40.33, and 15.66% of the participants were multigravida, primigravida, and grand-multigravida, respectively. The majority (87%) of mothers had ANC follow-up in their current pregnancy. In the large population, 255 (85%) had labor pain while 171 (578%) of mothers showed vaginal bleeding in the current pregnancy and 167 (55.67%) of mothers had cephalic presentation. 88.33% of pregnant women had no history of PROM. 97 (32.33%) of mothers had urinary tract infection in pregnancy, 32 (10.66%) had anaemia, and 41 (13.67%) had an abnormal vaginal discharge. The pregnant mothers had not used any cocaine, and cigarettes. Different risk factors associated with PPROM such as current urinary tract infection, gravidity, history of previous PPROM, preeclampsia, economic status, and anaemia were recorded. The major risk factors are use of smoking, chat, and cocaine. To lower the incidence of preterm premature rupture of membranes, early detection and treatment of urinary tract infections and atypical vaginal discharges were advised. Keywords: Preterm prelabour rupture of membranes; fetal outcome; Female urogenital disorders; maternal age; Pakistan

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Aim: Dentists have developed as both a novel potential treatment for the majority of the patients, and they are projected to play aa significant part in oral rehabilitation in future. The latest research was carried out to evaluate several parameters influencing the chance of survival of dental work. Methods: The current investigation was carried out in Services Hospital, Lahore. This study includes 5300 individuals who had dental implants implanted between June 2020 and May 2021. Individuals with hormonal imbalances, chronic infectious illnesses, immunosuppressive medication, pregnant women, drug and alcohol abusers, and suffering from chronic periodontal disorders have also been excluded. Name, age, gender, length of implant, diameter of implant, placement of implant, and biomechanical properties were among the parameters reported. Results: There were 2900 men and 2500 women among 5400 individuals. Highest implantation losses (56) were observed in patients above the age of 59 (males -560, females -740). There were 21 unsuccessful implantations in the 41-year-old age category (males 760, women 560). There were 46 unsuccessful implants in the age category 40-61 years (males -1600, women -1100). The change remained not statistically substantial (P = 0.22). Implant with a length of more than 12.6 mm (44/720) failed the most, followed by implant with a length of 11 mm (23/1670) and 11-11.6 mm (63/2870). The increase was statistical implication (P 0.06). Fasteners with just a diameter of 4.77 mm (17/1640) and implantation with a length of 5.77-3.6 mm (53/2700) failed the most (33/1050). Conclusion:The existence rate of prostheses is resolute by limitations just like age, entrenched length, diameter, bone quality, also implanted location. Researchers discovered that implants more than 12.6 mm in height and 4.76 mm in diameter, put in the mandibular posterior area of Type III bones, had the highest failure rate.