Pattern of gynaecological malignancies in south western region of Pakistan: An overview of 12 years

Abstract

Abstract. Gynaecological malignancies contribute significantly to cancer burden and have a higher rate of mortality and morbidity. The aim of this retrospective study was to determine the pattern of gynaecological malignancies identified between January, 2000 and December, 2011, at the Centre for Nuclear Medicine and Radiotherapy (CENAR). At CENAR 5,072 female patients were registered with different malignancies, of which 632 cases were gynaecological malignancies. Ovarian cancer (47%) was the most common gynaecological malignancy, followed by cervical cancer (29%), uterine cancer (14%), vulvar and vaginal cancer (6%), and gestational trophoblastic neoplasm (4%). Of the ovarian cancer cases, 72.5% had epithelial while 26.5% had non-epithelial cancer. Squamous cell carcinoma was 75.9% in cervix and 87.8% in vulva and vagina while endometrial carcinoma (75.9%) was more frequent in uterus. For gestational trophoblastic neoplasm, 69.2% of patients had choriocarcinoma. Ovarian cancer was the most common type for the age range of 50-59 years. In the case of cervical and gestational trophoblastic neoplasm the majority of patients presented at the ages of 40-49 and 30-39 years while uterus, vulvar and vaginal tumor presented in the elderly (>60 years). Thus, ovarian cancer is the leading gynecological malignancy in Pakistan.

Study on pattern of gynaecological malignancies at Saveetha Medical College and Hospital, Tamil Nadu, India

“…4 Contrary to this was reported from Pakistan, where ovarian cancer (72.5%) was the leading gynecological cancer. 3,6 In European countries endometrial cancers were the commonest female genital cancers. 12, 13 The second commonest cancer in our study was the ovarian malignancy followed by the corpus uteri cancer.…”

“…The median age of cancer cervix, ovary, and corpus uteri was 50, 48 and 48.5 years respectively, which is comparable with studies done by Agarwal et al 10 But according to SEER registry, the median age of occurrence of cervical cancer was lower (48 years) whereas ovarian and uterine cancers occurred at an older age group. 6,12 The mean age of women with insitu cancer cervix was 44 years. This correlates with the fact that premalignant changes begin early in the reproductive age group and has a long lead time before it becomes malignant.…”

Association of MTHFR 677C>T Polymorphism with Susceptibility to Ovarian and Cervical Cancers: A Systematic Review and Meta-Analysis

“…Moreover, cervical cancer is the third most frequent neoplasm among women worldwide (Rocha et al, 2017). In 2017, a study showed that ovarian cancer (47%) followed by cervical cancer (29%) are the most common gynecological malignancy among Pakistan women (Manzoor et al, 2017). Despite continuous advances in cancer biology research, the etiology of ovarian and cervical cancer are not known exactly, partly because of the inconsistency of findings among epidemiological studies (Yu et al, 2013).…”

Pattern of female gynecological malignancies in south Punjab Region of Pakistan: An overview of 5 years.

“…Almost similar results (48%) were found by Manzoor H et al in a study conducted in Pakistan. 15 Though it is more common in developed countries but the incidence is quite high in our study of developing country and might be the result of new trends in lifestyle which act as contributing factors like late conception, short families and lack of breast feeding. 16 Also the dietary habits of our population have changed tremendously over the last decade and this in combination with reduced physical activity has contributed to weigh gain in our female population.…”