A Case Report of Triple-Positive Micropapillary Carcinoma of the Male Breast

Abstract

Background: Micropapillary carcinoma (MPC), a morphologically distinct subtype of invasive ductal carcinoma, of the male breast is an exceedingly uncommon disease. Case Report: Herein, we report a case of triple-positive MPC of the male breast with axillary lymph node involvement and no recurrence for over 2 years. Specifically, a 60-year-old male patient presented with a hard, elastic, and well-defined painless mass in the right breast. The patient underwent unilateral (right) modified radical mastectomy with axillary clearance. Histopathology revealed MPC grade 3 and metastasis in 16/16 lymph nodes. Hormone receptor analysis demonstrated strong positivity (total score 08) for estrogen/progesterone receptors and overexpression (score 3+) of human epidermal growth factor receptor 2. The patient received adjuvant chemotherapy (6 courses of CAF: cyclophosphamide, doxorubicin, and 5-fluorouracil), radiation, and tamoxifen. The patient has remained disease-free for over 2 years. Conclusion: This study demonstrates that triple-positive MPC of the male breast as a rare malignancy appears to respond promisingly to multimodality treatment.

Invasive Micropapillary Carcinoma: A Rare Case of Male Breast Cancer

“…According to Gokce et al, hormone receptor negativity is hypothesized to exhibit more aggressive behavior in pure IMPC versus mixed cases, potentially accounting for our patient’s lack of significant metastasis compared to that expected from the literature [ 10 ]. Additionally, the initial stage at diagnosis has been implicated as another major factor for prognostic review [ 4 ]. The clinical stage of our patient was PT1c N1a Mx.…”

“…The clinical stage of our patient was PT1c N1a Mx. This poses a better approach to multimodal treatment therapy that can improve recurrence rates and overall survival in the patient [ 4 ].…”

“…This subtype of carcinoma is characterized by neoplastic cells in a nested papillary pattern within clear spaces resembling lymphatic vessels [ 2 , 3 ]. Additionally, it demonstrates an aggressive clinical course with early lymphovascular invasion [ 2 , 4 , 5 ]. We present a case of a 77-year-old man with PT1c N1a Mx invasive micropapillary carcinoma of the left breast and review the current literature.…”

A Very rare case report of male invasive micropapillary breast carcinoma in China and review of literature

“…HER-2 oncoprotein is a potentially useful prognostic marker for breast cancer in women, but there are few data on male HER-2 expression [17] . This case report also shows that HER-2 expression is deficient.…”