Invasive Micropapillary Carcinoma: A Rare Case of Male Breast Cancer

Coyle, Emily A; Taj, Hiffsa; Comba, Isin Yagmur; Vásquez, Jonathan; Zayat, Vania

doi:10.7759/cureus.10571

Cited by 5 publications

(5 citation statements)

References 11 publications

(21 reference statements)

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“…While micropapillary histological architecture is found in up to 2-8% of all breast cancers, pure micropapillary carcinoma is infrequent and comprises 0.9-2% of breast carcinomas [3]. The mean age of diagnosis is 59 years, and it is predominantly found in females, with only a few case reports for male IMPC in existence [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

A rare case of invasive micropapillary carcinoma of the breast

Verras¹,

Mulita²,

Tchabashvili³

et al. 2022

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Invasive micropapillary carcinoma (IMPC) is a rare, distinct histological subtype of breast carcinoma. While micropapillary histological architecture is found in up to 2-8% of all breast cancers, pure micropapillary carcinoma is infrequent and comprises 0.9-2% of breast carcinomas. Invasive micropapillary carcinoma is emerging as an oncological and surgical challenge due to a plethora of characteristics that constitute this histological pattern -interestingly, both elusive and aggressive. We present the case of a woman presenting with IMPC, who was primarily treated with tumour and lymph node marking, followed by primary systemic therapy (PST), and consequent oncoplastic surgery with sentinel lymph node biopsy. Our case report outlines the importance of awareness of histological subtypes in breast cancer by focusing on a case report of IMPC. The breast surgeon must be aware of the lymphotropic behaviour of this subtype and the high prevalence of lymph node involvement in such patients, and therefore focus on rigorous axillary assessment. One must not forget that, despite having a more aggressive biological profile, IMPC has demonstrated no difference in survival when compared to other histological subtypes, and treatment should conform to international guidelines with an emphasis on nodal staging.

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Section: Introductionmentioning

confidence: 99%

A rare case of invasive micropapillary carcinoma of the breast

Verras¹,

Mulita²,

Tchabashvili³

et al. 2022

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“…There are many studies supporting the effectiveness of the combination of adjuvant hormone therapy and chemotherapy. In surgical treatment, radical mastectomy and lymphnode dissection, which are associated with lower rates of local recurrence, are performed [17,18].…”

Section: Discussionmentioning

confidence: 99%

Invasive micropapillary type male breast cancer: a case report

Acar,

Şimşek,

Urfalı

et al. 2024

Eur Res J

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Male breast cancer is rarely seen and peaks at the age of 71. Hyperestrogenism, gonadal dysfunction, obesity, and alcohol are among the risk factors for male breast cancer. In hereditary cases, BRCA2 mutation is often observed. The most common symptom is a painless mass that is palpable behind the nipple. Most male breast cancers are ductal carcinomas (81%), papillary carcinomas (13%), and mucinous carcinomas (6%). The invasive micropapillary carcinoma of the breast is important due to its high rate of lymphnode metastasis, recurrence, and distant metastasis. Mortality is 50% higher in men with lymphnode involvement compared to non-involved cases. Furthermore, as the number of affected lymphnodes increases, the prognos is worsens. In this study, we examined a case of invasive micropapillary type male breast cancer with clinical presentation as a palpable mass, lymphnode involvement, and aimed to highlight the radiological considerations that need attention.

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“…Data on molecular typing characteristics of MBMC are limited. Coyle et al reported that a patient was positive for ER and PR, but negative for HER-2 [5] ; Ishita et al also reported a patient with MBMC who was positive for ER and PR, but negative for HER-2 [16] . It was noted in this case that both ER and PR were positive.…”

Section: Discussmentioning

confidence: 99%

“…Male breast micropapillary carcinoma (MBMC) has features of early metastasis, late staging, and poor prognosis [5] . At present, there is no clear diagnosis and treatment plan for MBMC, and the existing treatment measures are mostly based on the diagnosis and treatment experience of female breast cancer, and the treatment effect is not ideal.…”

Section: Introductionmentioning

confidence: 99%

Invasive Micropapillary Carcinoma: A Rare Case of Male Breast Cancer

Cited by 5 publications

References 11 publications

A rare case of invasive micropapillary carcinoma of the breast

A rare case of invasive micropapillary carcinoma of the breast

Invasive micropapillary type male breast cancer: a case report

A Very rare case report of male invasive micropapillary breast carcinoma in China and review of literature

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