23Urolithin A is a major metabolite produced by rats and humans after consumption of 24 pomegranate juice or pure ellagitannin geraniin. In this study, we investigated the were statistically significant at p < 0.05; however, treatment with urolithin A at 6 h 83 before inflammatory induction by carrageenan showed no effect (Fig. 2B) scan is a powerful tool for identifying the existence of conjugated forms in biofluids. 130For detection of urolithin A conjugates in mouse plasma, neutral loss scans were 131 performed for glucuronide and sulfates (Fig. 4). The peak due to glucuronide was 132 observed at 2.5 min in the neutral loss of 176 dalton scan data (Fig. 4A) and the mass 133 spectrum of the peak at 2.5 min showed the ion peak at m/z 403, corresponding to 134 urolithin A monoglucuronide (Fig. 4B) 149In this study, we investigated anti-inflammatory activity in the

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