In vivo anti-inflammatory and antioxidant properties of ellagitannin metabolite urolithin A

Abstract

23Urolithin A is a major metabolite produced by rats and humans after consumption of 24 pomegranate juice or pure ellagitannin geraniin. In this study, we investigated the were statistically significant at p < 0.05; however, treatment with urolithin A at 6 h 83 before inflammatory induction by carrageenan showed no effect (Fig. 2B) scan is a powerful tool for identifying the existence of conjugated forms in biofluids. 130For detection of urolithin A conjugates in mouse plasma, neutral loss scans were 131 performed for glucuronide and sulfates (Fig. 4). The peak due to glucuronide was 132 observed at 2.5 min in the neutral loss of 176 dalton scan data (Fig. 4A) and the mass 133 spectrum of the peak at 2.5 min showed the ion peak at m/z 403, corresponding to 134 urolithin A monoglucuronide (Fig. 4B) 149In this study, we investigated anti-inflammatory activity in the

Natural Dibenzo-α-Pyrones and Their Bioactivities

“…Most of urolithins (i.e., urolithins A, C, and D) exhibited antioxidant activity in a cell-based assay [6]. However, there have been contradictory reports on their antioxidant capacity [62,87]. Recently, urolithins were revealed to display both antioxidant and pro-oxidant activities depending on assay system and conditions by using oxygen radical absorbance capacity (ORAC) assay, three cell-based assays, copper-initiated pro-oxidant activity (CIPA) assay, and cyclic voltammetry.…”

Nutrient and polyphenolic composition of industrial strawberry press cake

“…Ellagitannins and their metabolites possess a number of health-promoting qualities, including antiviral, antibacterial, antioxidant, antimutagenic, and anticarcinogenic properties [18,19]. The health-promoting activity of polyphenol compounds was previously thought to be due to their strong antioxidant properties.…”

Health benefits of walnut polyphenols: An exploration beyond their lipid profile

“…Ishimoto and colleagues investigated the anti-inflammatory role of urolithin A in carrageenaninduced paw edema in mice (Ishimoto et al, 2011). The volume of paw edema was reduced 1 h after oral administration of urolithin A.…”