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This paper focuses on the application of magnetophoresis to a new cell patterning method. The principle was demonstrated by using a CoPt micromagnet array, producing regularly spaced magnetic traps where cells were confined without any contact under the effect of negative magnetophoresis. To obtain this effect, yeast cells (Saccharomyces cerevisiae), which are diamagnetic, were placed in an aqueous solution enriched in paramagnetic ions. Unlabeled (non-magnetic) cell manipulation by magnetophoresis requires the production of high magnetic field gradients, ensuring significant forces. Therefore, micromagnets are particularly interesting for our application, since the field gradient increases as magnet dimensions are reduced.

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The use of a semi-numerical model in order to optimize a magnetic micro-switch is proposed. It relies on a flexible sizing environment for which novel models based on sums, surface, and volume integrals necessary to express magnetic phenomena have been developed. Then, corresponding software components have been generated. This environment is applied to optimize a bi-stable out-of-plane magnetic micro-switch. The optimized micro-switch is dedicated to be used in optical micro-scanner application. Its main characteristics are high displacement (in excess of 100 m), low switching time, and current consumption (300 mA). Results demonstrate a performing and generic way for fast design by optimization.