Two gold complexes, [AuV4-MeOPh-(Phbipy)}Cl1CF3SO3 1 and [A~~~l(4-MeOPh-terpy)CII.(ClO~)~ 2 [CMeOPh-(Phbipy) = 4'-(4-methoxyphenyl)-6'-phenyl-Z,Z'-bipyridine, 4-MeOPh-terpy = 4'-(4-methoxyphenyl) -Z,Z',6',Z''-terpyridinel are prepared, and their interactions with calf-thymus DNA, poly(dG-dC)* and poly(dA-dT)2, investigated by spectroscopic means; in the reaction with ct DNA, 1 has a higher binding constant than 2, but the latter has a higher degree of AT specificity.
Intercalation of [PtII(dpp-C,N,N')(MeCN)]+ 1 (dpp-C,N,N' = C-deprotonated 2,9-diphenyl-l,lO-phenanthroline) and C-deprotonated 6-phenyl-2,2'-bipyridine, dppm = diphenylphosphinomethane) into calf-thymus DNA leads to a dramatic enhancement of the photoluminescence of the platinum(r1) complexes (Ill0 = 271 1, 117 2); a much weaker DNA binding affinity of 2 [ K = (4.2 * 0.3) X lo4 dm3 mol-11 than of 1 [ K = (1.0 * 0.1) x lo6 dm3 mol-'1
The synthesis and characterization of ruthenium(II) complexes, [Ru(cyclam)(bqdi)] x ZnCl(4) (1 x ZnCl(4); cyclam = 1,4,8,11-tetraazacyclotetradecane, bqdi = o-benzoquinonediimine), [Ru(cyclam)(nqdi)] x (ClO(4))(2) (2 x (ClO(4))(2); nqdi = 2,3-naphthoquinonediimine), and [Ru(cyclam)(phi)] x (ClO(4))(2) (3 x (ClO(4))(2); phi = 9,10-phenanthroquinonediimine), are described. The DNA binding properties and biological activity of the Ru(II) complexes were studied by various biophysical and cytological techniques. As expected, only 3 showed significant binding with DNA. The thermodynamic profile of the binding of 3 and DNA was constructed by analyzing the experimental data of absorption titration and UV melting studies with the McGhee equation, van't Hoff's equation, and the Gibbs-Helmholtz equation. Compound 3 binds double-stranded DNA with a binding constant of 5.0 x 10(4) M(-1) at 20 degrees C, and the binding mode of the complex to DNA was proved to be intercalative. Cytotoxicity and induced type of cell death of 1-3 were also investigated. Basically, metal complexes with ligands of molecular shape closely related to the structure of DNA are more likely to bind DNA and possess higher toxicity.
Intercalation of the [Pt~~(5,5'-Me2bpy)(4-ampy)2]2+ (5,5'-Me2bpy = 5,5'-dimethyL2,2'-bipyridine, 4-ampy = 4-aminopyridine) complex into calf-thymus DNA is accompanied by an observed hypochromicity in the UV-VIS spectral changes and an increase in both the intensity and lifetime of the emission of the platinum complex.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.