Novel luminescent cyclometaiated and terpyridine gold(III) complexes and DNA binding studies

Abstract

Two gold complexes, [AuV4-MeOPh-(Phbipy)}Cl1CF3SO3 1 and [A~~~l(4-MeOPh-terpy)CII.(ClO~)~ 2 [CMeOPh-(Phbipy) = 4'-(4-methoxyphenyl)-6'-phenyl-Z,Z'-bipyridine, 4-MeOPh-terpy = 4'-(4-methoxyphenyl) -Z,Z',6',Z''-terpyridinel are prepared, and their interactions with calf-thymus DNA, poly(dG-dC)* and poly(dA-dT)2, investigated by spectroscopic means; in the reaction with ct DNA, 1 has a higher binding constant than 2, but the latter has a higher degree of AT specificity.

A Bifunctional Platinum(II) Complex Capable of Intercalation and Hydrogen‐Bonding Interactions with DNA: Binding Studies and Cytotoxicity

“…Importantly, 1 is almost an order of magnitude less toxic to the CCD-19Lu normal cell line. 7.0493 (À0.001) C 5 7.4256 (À0.0002) C 6 7.2788 (0.004) G 7 7.7301 (À0.004) G 8 7.6570 (0.008) A 9 8.1150 (À0.005) 7.7124 (0.0025) T 10 7.1120 (À0.007) T 11 7.2301 (À0.0035) G 12 7.8336 (0.02)…”

Influence of the Polypyridyl (pp) Ligand Size on the DNA Binding Properties, Cytotoxicity and Cellular Uptake of Organoruthenium(II) Complexes of the Type [(η6‐C6Me6)Ru(L)(pp)]n+ [L = Cl, n = 1; L = (NH2)2CS, n = 2]

“…Concentrations of CT DNA were determined spectrophotometrically using the molar extinction coefficient ε 260 = 6600  -1 cm -1 . [51] All electronic absorption titrations were performed at 293 K. After sonication, buffered solutions of CT DNA gave a UV absorbance ration A 260 /A 280 of ca. 1.90, indicating that the DNA was sufficiently free of proton.…”

Bifunctional Bioorganometallic Iridium(III)–Platinum(II) Complexes Incorporating Both Intercalative and Covalent DNA Binding Capabilities

“…Concentrations of CT DNA were determined spectrophotometrically using the molar extinction coefficient ε 260 = 6600  -1 cm -1 . [37] All absorption titrations were performed at room temperature. After sonication, buffered solutions of CT DNA gave a ratio of UV absorbance A 260 /A 280 of ca.…”