Cyclometallated platinum(II) complexes as luminescent switches for calf-thymus DNA

Abstract

Intercalation of [PtII(dpp-C,N,N')(MeCN)]+ 1 (dpp-C,N,N' = C-deprotonated 2,9-diphenyl-l,lO-phenanthroline) and C-deprotonated 6-phenyl-2,2'-bipyridine, dppm = diphenylphosphinomethane) into calf-thymus DNA leads to a dramatic enhancement of the photoluminescence of the platinum(r1) complexes (Ill0 = 271 1, 117 2); a much weaker DNA binding affinity of 2 [ K = (4.2 * 0.3) X lo4 dm3 mol-11 than of 1 [ K = (1.0 * 0.1) x lo6 dm3 mol-'1

Synthesis and luminescent spectroscopy of lanthanide complexes with dimethylpyridine-2,6-dicarboxylate (dmpc)

“…This is most probably due to the ability of the smaller molecules of CH 3 OH (relative to DMSO and DMF molecules) to enter the coordination spheres of Eu(III) ions which quenches the luminescence intensities by the high vibrational frequency of C-H and O-H bonds of CH 3 OH [49]. The reasons behind this difference between Tb-dmpc and Eu-dmpc complexes are not well understood and may be not only owing to the solvate effect but also to the changes in the structures of the Eu(III) and Tb(III) complexes after adding the solvent [54][55][56].…”

A Bifunctional Platinum(II) Complex Capable of Intercalation and Hydrogen‐Bonding Interactions with DNA: Binding Studies and Cytotoxicity

“…Intercalation is the preferred binding mode for 2, whereas valent interactions would be a valuable principle in the development of new metal-based probes which recognize biomolecular targets with high specificity. [Pt(CNN)(L)] + (L = neutral ligand) complexes have been reported to display photoluminescence that is sensitive to the local microenvironment, [21,22] and they are structurally related to the wellknown intercalator [Pt(terpy)Cl] + . [23] Here we describe studies on DNA binding and cytotoxicity of the cyclometalated platinum(ii) complex [Pt(CNN)(4-dpt)]PF 6 (1) containing a pyridyl ligand that carries a triple hydrogen-bonding motif.…”

Solvent-induced formation of two novel mononuclear and dinuclear copper(II) complexes: Synthesis, structure and properties

“…S1). It appears to be owing to variations of the raising coordination abilities of DMF, DMSO, ethanol and acetone for the copper ions, which is solvate effect [33]. In summary, we have stressed on reaction conditions and obtained complexes 1 and 2 of different topology.…”