Background: The interaction between taste sensation and dentoalveolar innervation is still under research. teeth loss can alter taste thresholds in humans, but the underlying mechanisms are still obscure. This study investigated the effect of unilateral maxillary molars extraction on the structure of circumvallate papilla in rats. Methods: Thirty-two male Wister rats, aged 3-4 months were randomly distributed into four groups (one control and 3 experimental ) each including 8 animals. The rats were euthanized 3, 6 or 9 weeks following the procedure. The changes in trough length and the taste buds structure and number of both sides of CVP were investigated using routine histological examination followed by statistical analysis. Results: the trough toward the extraction side was obviously shorter with a noticeable decrease of taste buds’ number than the non-extraction side. Taste buds were reduced in size and most of them showed signs of degeneration which was more evident in group II followed by group III, less deformity detected in group IV in comparison to the preceding 2 experimental groups. the non-extraction side of all experimental groups showed normal trough length and generally normal histology of taste buds. Conclusions: Maxillary molars extraction has a degenerative effect on the structure of taste buds and gustatory epithelium which were more marked at the extraction side and showed improvement upon elongation of follow up period
Aim:The aim of the present study to evaluate the potential effect of Sodium Alendronate on tooth eruption and root formation in young growing and osteoporotic albino rats .Materials and Methods Sixty newborn wister albino rats with their average weight 6 grams, each were used in the study. Rats were divided into 4 groups (groupI, groupII, group III &group IV) : GI negative control, GII positive control, GIII Alendronat treated group, GIV (alendronate + dexamethasone) then each group was divided into 3 subgroups according to the date of scarification at7,14,30 days. Rats were subjected to subcutaneous injection of sodium alendronate and dexamethasone in their dorsal back. The specimens were processed for histological and histochemical analysis. Results: alendronate prevented tooth eruption and root formation but dexamethasone caused resorption of bone over developing molar but didn't affect molar eruption and root formation. Conclusion: sodium alendronate caused increase in bone formation and obstructed eruption pathway. Sodium alendronate prevented maturation of alveolar bone while dexamethasone caused destruction of alveolar bone but didn't affect normal tooth eruption.
Background: Bone defects resulting from trauma, tumor resection, infection, and congenital or acquired deformities remains an important clinical problem. Synthetic nano-crystalline hydroxyapatite, Nano bone, was successfully used in healing of bone defects without revealing negative side effects. Biodentine; a calcium-silicate based material was reported to have osteogenic and angiogenic properties.Objectives: This study aims to investigate the initial osteoinductive potential of Nano Bone and Biodentine on surgically created defects in rabbit's alveolar process. Methods: 30 adult male rabbits (1-1.5kg) were used in this study. Bilateral bone defects were created in the mandibles of all rabbits, one in each side; the right sides were experimental, and the lefts were kept empty as control. Animals were then divided into two groups (15 rabbits each); Group I (Biodentine): The right-side defects were loaded with Biodentine material. Group II (Nano Bone): Nano Bone was packed in the right-side defects. Five rabbits were euthanized from each group at; 3, 7 and 14 days postoperatively. Bone defects' specimens were prepared for histological examination by light microscope as well as quantitative analysis of gene expression of collagen1 alpha and Runx-2 by real time PCR. Results: Biodentine had initiated osteogenesis; yet the newly formed bone was apparently of lesser quality than that formed with Nano Bone. Runx-2 showed significant increase in Nano Bone compared to Biodentine at 1 week, while collagen1 alpha gene expression was significantly increased at all intervals. Conclusion: Both Nano Bone and Biodentine had initiated osteogenesis. Nano bone showed better healing results when compared to Biodentine.
Aim of the study: The cause of a tooth loss may have an impact on the bone quality at this specific site affecting its Osseo integrative potential. The present study was designed to investigate bone quality and activity in implant fixation sites of congenitally missing teeth compared to others of healed extraction ones.Methods: 10 core biopsies were collected during implant fixation procedure; 5 from sites of healed extraction and 5 from sites of congenitally missing un-grafted ridge. They were all from the same jaw with no predilection of anterior or posterior. The specimens were processed for histological, morphometric & gene expression of RANKL & vitamin D receptors (VDR).Results: histological examination with hematoxylin and eosin showed different bone architecture between the two groups with apparent more intact appearance of the healed extraction group. histomorphometry revealed significant difference between the two groups in the total bone area percentage in favor of the healed extraction group. gene expression values of vitamin D receptors, as well as RANKL, recorded a significant decrease in the congenitally missing samples when compared to the healed extraction ones.Conclusion: the results of the present work suggest the possible effect of cause of tooth loss on the quality of the residual bone which may affect the osteointegration potential in the area that reflects on implant survival rates. More detailed investigation is recommended to include: different areas, different gender as well as involving more growth factors.
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