Gustatory dysfunction in relation to circumvallate papilla’s taste buds structure upon unilateral maxillary molar extraction in Wistar rats: an in vivo study

Abstract

Background: The interaction between taste sensation and dentoalveolar innervation is still under research. teeth loss can alter taste thresholds in humans, but the underlying mechanisms are still obscure. This study investigated the effect of unilateral maxillary molars extraction on the structure of circumvallate papilla in rats. Methods: Thirty-two male Wister rats, aged 3-4 months were randomly distributed into four groups (one control and 3 experimental ) each including 8 animals. The rats were euthanized 3, 6 or 9 weeks following the procedure. The changes in trough length and the taste buds structure and number of both sides of CVP were investigated using routine histological examination followed by statistical analysis. Results: the trough toward the extraction side was obviously shorter with a noticeable decrease of taste buds’ number than the non-extraction side. Taste buds were reduced in size and most of them showed signs of degeneration which was more evident in group II followed by group III, less deformity detected in group IV in comparison to the preceding 2 experimental groups. the non-extraction side of all experimental groups showed normal trough length and generally normal histology of taste buds. Conclusions: Maxillary molars extraction has a degenerative effect on the structure of taste buds and gustatory epithelium which were more marked at the extraction side and showed improvement upon elongation of follow up period

Effects of dose-dependent response to gamma radiation on circumvallate papilla by expression of caspase-3 in vivo

“…We selected circumvallate papilla as an indicator of oral mucosal changes with gamma radiation. Moreover, there is an opportunity to evaluate the taste bud reaction as circumvallate papillae gathering numerous taste buds in one localized region ( Mostafa et al, 2019 ) .…”

The Effect of Stem Cells Exosomes on Circumvallate Papillae of Albino-Rats Subjected to Cyclophosphamide Chemotherapy

“…After sacrificing the rats, the tongues were excised free. The circumvallate papilla (CVP) is found most posteriorly in the middle of the anterior two-thirds of the tongue, the location of the CVP in the tongue was identified, and then the tissue specimen was isolated by two oblique cuts posteriorly and a cut anterior to the papilla (8) .…”

La desaferentación dental como factor etiológico de disfunciones gustativas en ratas Wistar machos

“…Sin embargo, los déficits gustativos que siguen a la exodoncia de otras piezas dentales (molares superiores, incisivos, etc.) o tratamientos de conducto radicular no pueden explicarse por el daño del nervio cuerda del tímpano o glosofaríngeo, ya que las fibras nerviosas de estos nervios no inervan ni atraviesan el sitio quirúrgico anterior (10)(11)(12).…”