Evaluation of socket healing in irradiated rats after diode laser exposure (histological and morphometric studies)

Korany, Nahed Sedky; Mehanni, Samah; Hakam, Heba M.; El-Maghraby, Eman M.F.

doi:10.1016/j.archoralbio.2012.01.009

Cited by 42 publications

(40 citation statements)

References 34 publications

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“…Most included studies showed evidence that laser improved wound healing after tooth extraction surgery. LLLT with CO 2 , GaAlAs, Nd:YAG, and High‐frequency Pulsed Diode Laser in animal experiments showed an improvement in the wound healing process and bone repair when compared with control . The only study that used HLLT to coagulate blood and prevent the loss of blood clots before CO 2 laser application (1 W and 10.6 μm applied immediately after tooth extractions) also showed that 7 days after surgery, new bone formation started from the superficial onto the middle layer of the alveolus in the laser group, and around the extraction socket in the control group.…”

Section: Discussionmentioning

confidence: 94%

“…Only one animal experiment showed that laser therapy with HeNe laser did not improve wound healing . All other studies showed that laser application was beneficial in the wound healing process after tooth extraction …”

Section: Resultsmentioning

confidence: 99%

“…Although there are numerous applications for therapeutic lasers, their benefits in enhancing the wound healing process after tooth extraction is controversial . The purpose of this systematic review was to assess the best evidence that showed whether laser therapy was beneficial in wound healing after tooth extraction or not.…”

mentioning

confidence: 99%

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Does laser therapy improve the wound healing process after tooth extraction? A systematic review

Lemes

Rosa

Sonego

et al. 2018

Wound Repair Regeneration

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Laser therapy could amplify the oral wound healing process by stimulating cell regeneration after injury, attenuating pain, and modulating the immune system. The purpose of this systematic review was to evaluate whether the application of laser therapy improved alveolar healing after tooth extractions. Eight electronic databases were screened: MedLine (PubMed), The Cochrane Library, Web of Science, Scopus, Lilacs, Ibecs, Scielo, and BBO. Three reviewers independently assessed the title and abstracts of potentially relevant studies. Only clinical trials and animal experiments that evaluated the wound healing effect of laser therapy after tooth extraction were included. A total of 16 studies fulfilled all criteria, thus 8 animal experiments and 8 clinical trials were included. Different types of laser were evaluated, such as CO2, GaAlAs, Nd:YAG, Diode Laser, HeNe, and High‐frequency Pulsed Diode Laser. Although HF, Diode and GaAs lasers were able to enhance wound healing process in clinical studies, four trials and one animal experiment showed no improvement in wound healing with laser therapy after tooth extractions. In general, the current available evidence in the literature showed that laser therapy improved the wound healing process, but these findings were limited to the type of laser applied and its specific settings. Further well‐designed and randomized controlled trials are needed to support a benefit effect of using laser therapy after tooth extraction. PROSPERO registration number: CRD42014007509 (2014).

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Section: Discussionmentioning

confidence: 94%

Section: Resultsmentioning

confidence: 99%

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Does laser therapy improve the wound healing process after tooth extraction? A systematic review

Lemes

Rosa

Sonego

et al. 2018

Wound Repair Regeneration

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“…El-Maghraby [22] in a histological analysis showed a significant increase in the area of bone trabeculae, as well as the width of compact bone, for the lasered side of gamma irradiated mandibles of rats. Korany et al [23] found that LLLT enhance bone repair in irradiated tooth sockets of albino rats. Garcia et al [24] demonstrated that the LLLT was effective for stimulating bone formation in critical sized defects in the calvaria of rats submitted to ovariectomy.…”

Section: Discussionmentioning

confidence: 99%

Effect of Diode Laser on Healing of Tooth Extraction Socket: An Experimental Study in Rabbits

Hamad

Naif

Abdullah

2015

J. Maxillofac. Oral Surg.

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Objectives To evaluate the effect of low-level laser therapy on healing of extracted tooth socket of healthy rabbits. Design The sample of this study was 20 male rabbits of 2-2.5 kg weight with age range of 8-12 months. Right and left lower first premolar teeth were extracted. The extraction sockets of lower right first premolar were irradiated with 0.9 W gallium-aluminum-arsenide (GaAlAs) diode laser for 5 min, immediately after extraction and then every 72 h for the next 12 days. The extraction socket of left side were not exposed to laser and served as a control. The animals were sacrificed after 7, 14, 30 and 45 days and the experimental and control sockets were removed from the harvested mandibles and prepared for haematoxylin and eosin staining and Masson's stain. The prepared slides were examined under light microscope for histological and histomorphometric examination. Results The histological examination showed that diode laser-treated sockets demonstrated early formed new bone with faster maturation of primary bone to secondary bone as compared to non-treated control sockets. Histomorphometric analysis revealed a statistically significant increase in the density and volume of trabecular bone in lasertreated sockets than control sockets. Conclusion Diode laser application to tooth extraction socket has a positive effect on bone formation.

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“…Añadir el láser terapéutico después de la extracción reduce la fase infl amatoria, reduce el dolor, estimula los fi broblastos, aumenta la microcirculación y estimula los osteoblastos en el alvéolo; y debe utilizarse durante el periodo de cicatrización inicial, cuando la actividad proliferativa se eleva (5)(6)(7)(8).…”

Section: Introductionunclassified

Efecto del láser terapéutico infrarrojo en la reparación ósea post-exodoncia en ratas albinas

Cruz¹,

Torre²,

Sánchez³

et al. 2017

Rev Estomatol Herediana.

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Efecto del láser terapéutico infrarrojo en la reparación ósea post-exodoncia en ratas albinasEffect of therapeutic laser infrared in the bone repair post extraction in albino rats. Christiam Paolo Llapapasca Cruz RESUMENObjetivos: Determinar el efecto del láser terapéutico infarrojo en la reparación ósea post exodoncia en ratas Albinas. Material y métodos: Treinta ratas Albinas Holtzman fueron divididos al azar en tres grupos (A, B y C) de 10 ratas cada uno de acuerdo al día de sacrifi cio y subdivididos en dos grupos teniendo 5 ratas cada uno (A1, A2, B1, B2, C1, C2). A los alvéolos de los incisivos superiores extraídos de las ratas de los grupos A1, B1 y C1 no se les aplicó el láser terapéutico infrarrojo siendo el control y a los alvéolos de las ratas de los grupos A2, B2 y C2 se les aplicó el láser terapéutico infrarrojo AsGaAl de forma puntual y continua. Las muestras se analizaron utilizando un Microscopio Óptico mediante conteo celular y estructuras nuevas del alvéolo. Resultados: A los 3 días se encontró una cantidad mayor de neutrófi los, linfocitos, macrófagos, fi broblastos y neovasos en los grupos láser pero sólo fue estadísticamente signifi cativo en macrófagos (p = 0,026). A los 7 días se encontró un cantidad mayor de fi broblastos y neovasos en los grupos láser siendo estadísticamente signifi cativos (p = 0,01 y p = 0,008 respectivamente). A los14 días se encontraron osteoblastos pero en mayor cantidad en los grupos láser, siendo estadísticamente signifi cativo (p = 0,008). Conclusiones: El láser terapéutico infrarrojo presentó efecto positivo en la reparación ósea post exodoncia modulando la respuesta celular y bioestimulando la formación de nuevas células y estructuras involucradas en las etapas de cicatrización del alvéolo.

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Evaluation of socket healing in irradiated rats after diode laser exposure (histological and morphometric studies)

Cited by 42 publications

References 34 publications

Does laser therapy improve the wound healing process after tooth extraction? A systematic review

Does laser therapy improve the wound healing process after tooth extraction? A systematic review

Effect of Diode Laser on Healing of Tooth Extraction Socket: An Experimental Study in Rabbits

Efecto del láser terapéutico infrarrojo en la reparación ósea post-exodoncia en ratas albinas

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