Atopic dermatitis (AD) is a chronic relapsing inflammatory skin disorder with significant morbidity and impairment of life quality. Prevalence is increasing around the world; therefore, intensive research is ongoing to understand the mechanisms of development of AD and offer new treatment options for AD patients. Aims: To investigate the association between Inflammatory (IL-17, TNFα, IFNγ) versus anti-Inflammatory Cytokines (IL-35, TGFβ) in AD patients. Patients and Methods: A case control study included 40 AD patients and 20 ageand sex-matched healthy subjects. Cases were subjected to full history taking and full dermatological examination. The assessment of disease severity was conducted by using SCORAD score. Assessment of inflammatory (IL-17, TNFα, IFNγ) and anti-Inflammatory Cytokines (IL-35, TGFβ) was performed by using ELISA technique. Results:The mean level of TNFα, IL-17 was statistically significantly higher in the AD cases as compared with the control group. The mean level of TGFβ, Il-35, and IFNγ was statistically significantly lower in the Atopic dermatitis cases as compared with the control group. There was statistically significant strong positive correlation between TNFα with SCORAD score and IL-17 while there was statistically significant strong negative correlation between TNFα with TGFβ and IL-35. There was statistically significant strong positive correlation between IL-17 with SCORAD score and TNFα while there was statistically significant strong negative correlation between IL-17 with TGFβ and IL-35. Conclusion:The current results could be used as a clue for the utilization of inflammatory (IL-17, TNFα, IFNγ) versus anti-inflammatory Cytokines (IL-35, TGFβ) in AD as a diagnostic biomarker for severity of cases with Atopic dermatitis. IL-17 plays an important role in the pathogenesis of AD, and IL-17 blocker may be used as a potential future treatment of AD.

Background: Many treatment options were used for Vitiligo. But there is no consensus on the precise treatment modality. Aim of the work:The study aimed to assess and compare the efficacy of microneedling combined with trichloracetic acid [TCA] versus micro-needling with tacrolimus in the treatment of Vitiligo, Patients and Methods: 60 Vitiligo were included and classified into two equal groups. Group [A] included 30 patients who received micro-needling with dermapen then tacrolimus 0.03 ointments every two weeks for six sessions. Group B included thirty patients who received micro-needling with dermapen then TCA 25% every two weeks for six sessions. The outcome was documented. Results: The repigmentation was slightly higher in TCA-treated patches than with tacrolimus. Excellent response in repigmentation occurred in 43.3%of TCA patches. In contrast, in 16.7% of tacrolimus-treated patches, Good improvement occurred in13.3% of TCA-treated patches while 23.3% of tacrolimustreated patches. Moderate improvement occurred in10.0% TCA -treated patches while 30.0% of tacrolimus-treated patches, mild improvement occurred in 13.3% of TCA -treated patches. In comparison, only in 16.7% of tacrolimus-treated patches, However, there was a great difference between the two drugs regarding erythema, inflammation, and exfoliations, which occurred mainly with TCA. Conclusion:The mix of microneedling with either TCA 25% or tacrolimus is effective and safe in treating Vitiligo.However, TCA achieved a slightly increased percentage of repigmentation than tacrolimus.

Background: Acne is one of the commonest chronic inflammatory dermatological disease among adolescents. Aim of the Work: The aim of the study was to detect the prevalence of acne among pre adolescents in primary and preparatory schools in Damietta governorate Egypt. Patients and Methods: This was a cross sectional study, that was conducted on 1624 pre adolescents in primary and preparatory schools in Damietta governorate. Results: Age ranged from 8-13 years with mean value 11.44±1.680 years. Male cases were 781 [48.1%] while female cases were 843 [51.9%] and 251[65.8%] had mild acne grade, 122[31.9%] had moderate acne grade and 9[2.4%] had severe acne grade. Conclusion: Acne is one amongst the most common skin disease and includes a great effect on quality of life among pre adolescents attending primary and preparatory schools in Damietta governorate, the prevalence of acne vulgaris among pre adolescents in primary and preparatory schools in Damietta governorate Egypt was 23.5%.

Background; The visible result of a human papillomavirus (HPV) infection caused by one or more of the roughly 100 known strains is genital warts. The most prevalent STD in the world is HPV, and infections with it are strongly linked to major morbidity and death. Numerous malignancies and lesions of the mucosa and epithelium are caused by HPV. Women under the age of 25 are most typically affected by HPV infections, Aim and objectives; to evaluate the efficacy and safety of topical hydrogen peroxide solution 40% in treatment of genital warts, Subjects and methods; this study was a randomized controlled trial that was conducted on 52 patients attending the Dermatology outpatient clinic at Damietta Faculty of Medicine, Al-Azhar University. The selected subjects were divided into 26 patients treated with topical H2O2 as Hydrogen peroxide group and 26 patients treated with saline as control group. Result; There is statistically significant positive correlation between Size of wart after ttt and number of wart after ttt. There is statistically significant reduction in the number of warts with decrease its number after ttt. However, there is no statistically significant correlation between the size and number of warts after ttt with other clinical variables, Conclusion; One possible course of therapy for genital warts may be hydrogen peroxide solution, particularly the 40% concentration. As a novel topical therapy for genital warts, it is very efficient, secure, affordable, and simple to apply,