Atopic dermatitis (AD) is a chronic relapsing inflammatory skin disorder with significant morbidity and impairment of life quality. Prevalence is increasing around the world; therefore, intensive research is ongoing to understand the mechanisms of development of AD and offer new treatment options for AD patients. Aims: To investigate the association between Inflammatory (IL-17, TNFα, IFNγ) versus anti-Inflammatory Cytokines (IL-35, TGFβ) in AD patients. Patients and Methods: A case control study included 40 AD patients and 20 ageand sex-matched healthy subjects. Cases were subjected to full history taking and full dermatological examination. The assessment of disease severity was conducted by using SCORAD score. Assessment of inflammatory (IL-17, TNFα, IFNγ) and anti-Inflammatory Cytokines (IL-35, TGFβ) was performed by using ELISA technique. Results:The mean level of TNFα, IL-17 was statistically significantly higher in the AD cases as compared with the control group. The mean level of TGFβ, Il-35, and IFNγ was statistically significantly lower in the Atopic dermatitis cases as compared with the control group. There was statistically significant strong positive correlation between TNFα with SCORAD score and IL-17 while there was statistically significant strong negative correlation between TNFα with TGFβ and IL-35. There was statistically significant strong positive correlation between IL-17 with SCORAD score and TNFα while there was statistically significant strong negative correlation between IL-17 with TGFβ and IL-35. Conclusion:The current results could be used as a clue for the utilization of inflammatory (IL-17, TNFα, IFNγ) versus anti-inflammatory Cytokines (IL-35, TGFβ) in AD as a diagnostic biomarker for severity of cases with Atopic dermatitis. IL-17 plays an important role in the pathogenesis of AD, and IL-17 blocker may be used as a potential future treatment of AD.

Psoriasis is an autoimmune disorder mediated by T-lymphocytes with skin, nail, and joint involvement. PsO influences 2%-3% of general population. 1 Its main characteristic is the symmetrical distribution of well-defined, reddish plaques with adherent silvery-white scales covering patient's body. 2 Psoriasis is born of an interaction of innate and adaptive immunity together with genetic factors. 3 T-lymphocytes and pro-inflammatory cytokines have a major role in the pathogenetic process of psoriasis.

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