Sensitive detection of glucose using a glassy carbon electrode modified with glucose oxidase and multi-walled carbon nanotubes decorated with palladium nanoparticles.
A facile and green route for the synthesis of copper nanoparticles (Cu NPs) has been achieved using green tea extract as a reducing, capping and stabilizing agent. UV-visible spectra gave surface plasmon resonance at 560 nm. The Cu NPs were characterized using various techniques. The size of the Cu NPs was about 20 nm. Antibacterial activity of biogenic Cu NPs were investigated against bacterial species Staphylococcus aureus, Bacillus subtilis, Pseudomonas aeruginosa and Escherichia coli and compared based on diameter of inhibition zone in disc diffusion assay and minimum inhibitory concentration and minimum bactericidal concentration of NPs dispersed in liquid cultures. The NPs showed better inhibitory activity against Gram-positive bacteria (S. aureus and B. subtilis) compared to Gram-negative bacteria. Toxicity of the NPs was evaluated against animal cell line using MTT assay.
BackgroundNoble metal nanoparticles, due to their good physicochemical properties, have been exploited in biological applications. Among these metals, nanosilver has attracted great attention because of its optical properties and broad-spectrum antimicrobial activities with no drug tolerance.PurposeThe present study has attempted to conduct chemical synthesis of Fe3O4@PEG-Ag core/shell nanocomposites in aqueous solutions through co-precipitation of Fe3+ and Fe2+ ions, encapsulating the iron oxide core by poly (ethylene-glycol) (PEG) improve its hydrophilicity and biocompatibility, and immobilizing silver ions by application of NaBH4 as a reducing agent.Patients and methodsThe synthesized structures were characterized by Fourier-transform infrared (FT-IR), field emission scanning electron microscopy, energy-dispersive X-ray spectrum, wavelength-dispersive X-ray, vibrating sample magnetometer, inductively coupled plasma-mass spectrometry and transmission electron microscopy methods. Antimicrobial activity of the nanostructures against Staphylococcus aureus, Escherichia coli and Candida albicans was evaluated by broth microdilution based on the methods suggested by Clinical Laboratory Standard Institute. Furthermore, the nanocomposite was tested for possible anti-parasitic effects against Leishmania major promastigotes by MTT assay. Also, its impacts on bacterial cell morphology were defined using atomic force microscopy. Moreover, toxicity of the nanostructure related to animal cell line was determined based on MTT assay.ResultsIn general, the synthesized core/shell nanostructure can demonstrate noticeable activity against the evaluated representative microorganisms while its toxicity against animal cell line is not considerable.ConclusionThis nanostructure can be applied as a smart drug delivery system with the help of an external magnetic field or it can be used as a powerful antibiotic agent along with other antibiotics that can form a shell on its structure.
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