This study was performed to evaluate pathology of experimental Encephalitozoon cuniculi (Iraqi isolate) infection in normal and immunosuppressed mice. Pathological changes were not seen in negative control mice while secondary bacterial infections were noted in the lungs, kidneys, and heart of mice given dexamethasone. Typical E. cuniculi infection lesions were found in brain, livers, lungs, and kidneys of mice given 107   E. cuniculi spores/mouse orally. These lesions were in the form of nonsuppurative meningoencephalitis with vasculitis in brain, interstitial inflammation with infiltration of both lymphocytes and plasma cells in lung tissue, and nonsuppurative interstitial (focal and diffuse) nephritis, presence of vacuole containing mature and immature spores in enterocytes within the tips of villi, and lymphoiod hyperplasia of the white pulp and vasculitis of the intratrabecular vessels. Mice that were given 107   E. cuniculi spores/mouse orally showed lesions similar to those observed in the previous group (vasculitis and granulomas) but the lesions were more severe and widespread. In conclusion, this is the first report of experimental E. cuniculi infection induced by E. cuniculi isolated from a naturally infected rabbit in Iraq and that infection became more severe and widespread upon the administration of dexaethasone.

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The age and sex incidence, monthly and seasonal occurrence, signs and symptoms, clinical pathological changes and gross lesions associated with hookworm disease in 264 dogs are described. Less commonly reported clinical signs have been pointed out. The impact of concurrent infection with babesiosis is discussed.

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The current study included the identification of lesions and the histological changes caused by Toxoplasma gondii, which was isolated from embryos of aborted ewes. 15 female albino rats (3 months old) was injected intraperitonia with suspension containing 100 tissue cysts. After four months of injection, the histological section showed a chronic infection characterized by autolysis in all sections, where the liver sections showed expansion of the central hepatic veins, congestion in sinusoidal with irregularity in hepatic cords, and the presence of the parasites in the liver cells and Kupffer. The brain tissue showed vacuoles in the neurons with an increase in the number of Purkenji cells. Kidney sections were characterized by degenerative and necrotic changes in the endothelial cells of the proximal and distal convoluted tubules with Sloughing of necrotic and degenerated cells of the tubes, which accumulated inside the lumen. The parasites appeared in the endothelial cells of the glomerular tufts. Ovary and the uterus showed increased vascular wall thickness, furthermore, the spleen showed autolytic changes, pigment deposition with the presence of parasites within the cells.

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