The current study included the identification of lesions and the histological changes caused by Toxoplasma gondii, which was isolated from embryos of aborted ewes. 15 female albino rats (3 months old) was injected intraperitonia with suspension containing 100 tissue cysts. After four months of injection, the histological section showed a chronic infection characterized by autolysis in all sections, where the liver sections showed expansion of the central hepatic veins, congestion in sinusoidal with irregularity in hepatic cords, and the presence of the parasites in the liver cells and Kupffer. The brain tissue showed vacuoles in the neurons with an increase in the number of Purkenji cells. Kidney sections were characterized by degenerative and necrotic changes in the endothelial cells of the proximal and distal convoluted tubules with Sloughing of necrotic and degenerated cells of the tubes, which accumulated inside the lumen. The parasites appeared in the endothelial cells of the glomerular tufts. Ovary and the uterus showed increased vascular wall thickness, furthermore, the spleen showed autolytic changes, pigment deposition with the presence of parasites within the cells.
The current study included the identification of lesions and the histological changes caused by Toxoplasma gondii, which was isolated from embryos of aborted ewes.
15 female albino rats (3 months old) was injected intraperitonia with suspension containing 100 tissue cysts.
After four months of injection, the histological section showed a chronic infection characterized by autolysis in all sections, where the liver sections showed expansion of the central hepatic veins, congestion in sinusoidal with irregularity in hepatic cords, and the presence of the parasites in the liver cells and Kupffer. The brain tissue showed vacuoles in the neurons with an increase in the number of Purkenji cells. Kidney sections were characterized by degenerative and necrotic changes in the endothelial cells of the proximal and distal convoluted tubules with Sloughing of necrotic and degenerated cells of the tubes, which accumulated inside the lumen. The parasites appeared in the endothelial cells of the glomerular tufts. Ovary and the uterus showed increased vascular wall thickness, furthermore, the spleen showed autolytic changes, pigment deposition with the presence of parasites within the cells.
The present study aimed at investigation of the histopathological changes which may occur in mice due to experimental infection with protoscoleces of Echinococcus granulosus of different host origin.Whitish-yellow nodules of different size, ranging between pinpoint and 0.5cm in diameter, both solid and cystic in structure, were observed in the liver and spleen of the infected mice. Further investigation revealed that these nodules indicate that they are tumor cells.
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