Ovine placenta related to binucleated cells in fetal membrane retention

Majeed, A.F.; Al-Sadi, H. I.; Ridha, Abduh

doi:10.1016/0921-4488(95)00648-5

Cited by 2 publications

(1 citation statement)

References 15 publications

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“…Perhaps expression of MHC class I proteins by BNC sensitizes the maternal immune system to induce a tolerogenic environment in the uterus of the cow. Moreover, the persistence of BNC cells at the time of parturition has been correlated to retention of foetal membranes in sheep (Majeed et al 1995), possibly due to the lack of inflammatory signals necessary for placental detachment after parturition. Furthermore, the majority of MHC class I molecules expressed by the bovine trophoblast are non-classical (NC) genes (Davies et al 2006).…”

Section: Mhc Proteins Expression By the Trophoblastmentioning

confidence: 99%

Modulation of Maternal Immune System During Pregnancy in the Cow

Oliveira

Barreto

Perecin

et al. 2012

Reprod Domestic Animals

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Contents There is a molecular crosstalk between the trophoblast and maternal immune cells of bovine endometrium. The uterine cells are able to secrete cytokine/chemokines to either induce a suppressive environment for establishment of the pregnancy or to recruit immune cells to the endometrium to fight infections. Despite morphological differences between women and cows, mechanisms for immune tolerance during pregnancy seem to be conserved. Mechanisms for uterine immunesuppression in the cow include: reduced expression of major histocompatability proteins by the trophoblast; recruitment of macrophages to the pregnant endometrium; and modulation of immune‐related genes in response to the presence of the conceptus. Recently, an eGFP transgenic cloned embryo model developed by our group showed that there is modulation of foetal proteins expressed at the site of syncytium formation, suggesting that foetal cell can regulate not only by the secretion of specific factors such as interferon‐tau, but also by regulating their own protein expression to avoid excessive maternal recognition by the local immune system. Furthermore, foetal DNA can be detected in the maternal circulation; this may reflect the occurrence of an invasion of trophoblast cells and/or their fragment beyond the uterine basement membrane in the cow. In fact, the newly description of exosome release by the trophoblast cell suggests that could be a new fashion of maternal‐foetal communication at the placental barrier. Additionally, recent global transcriptome studies on bovine endometrium suggested that the immune system is aware, from an immunological point of view, of the presence of the foetus in the cow during early pregnancy.

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Section: Mhc Proteins Expression By the Trophoblastmentioning

confidence: 99%

Modulation of Maternal Immune System During Pregnancy in the Cow

Oliveira

Barreto

Perecin

et al. 2012

Reprod Domestic Animals

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Histology of ovine placenta during gestation periods

Majeed¹,

Shalal²,

Mohammed³

2012

Kufa Jou. Vete. Med. Sci.

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Placetomes were collected from 93 pregnant slaughtered Ewes at different gestation periods , from AL.Falluja slaughter house during the periods from 2, Jully 2009 to 30, December ,2010 . Tissue specimens for microscopic examination were taken from the centers of the sampled placentomes .Immediately following collection ,the samples were fixed in 10% bufferd neutral formalin for 24 h .Tissue specimens were dehydrated in a graded series of alcohol , cleared by xylol and embded in paraffin .Histologic section were cut at 3-4 µm thickness ,Stained with hematoxylin and eosin(H&E) (6).The period of gestation were measured according to Richardson (7) with aquation of x =2.1(Y+17) as x= gestation period in day and Y=the crown Rump Histologic examination during early pregnancy (30 – 40 d) Showed a pronounced BNC with anumbe of nuclei with in each cellular boundary in the uterine epithelium indicates that possible fusions are restricted , It is also there is an increase in blood vascularity. At 40 – 50 d of pregnancy, there was a further increase in caruncular vascularity by 2-fold characterized by increase capillary number and 2 to 3 – fold increase in capillary diameter. Endometrial gland hyperplasia showed during this period . Then placentomes showed grow in number and size until 8oth day. It was shown that the BNCS of the trophoblast increase in size, in polarity and in the number of their cytoplasmic granules as pregnancy advanced.

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Ovine placenta related to binucleated cells in fetal membrane retention

Cited by 2 publications

References 15 publications

Modulation of Maternal Immune System During Pregnancy in the Cow

Modulation of Maternal Immune System During Pregnancy in the Cow

Histology of ovine placenta during gestation periods

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