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Silver inlaid with gold nanoparticles (Au-Ag NPs) prepared by using egg white with an average sized of 10 nm and homogeneous dispersion were tested and presented red fluorescence. Au-Ag NPs were loaded into chitosan as wound dressing (CS-Au-Ag). CS-Au-Ag released silver ions faster, in higher amount, and in a more durable manner than chitosan dressing loaded with silver nanoparticles with the same silver content (CS-Ag), consequently, showing enhanced antibacterial activity. Cytotoxicity tests indicated that CS-Au-Ag showed low cytotoxicity to L929 cells similar to CS-Ag. These data suggest that cytotoxicity, which restricts further application of silver NPs, can be eliminated by decreasing the silver content. CS-Au-Ag presented rich and well-distributed pores, good mechanical properties, and enhanced swelling and retention properties, contributing to keeping the wound moist in the presence of residual egg white. Altogether, our results suggest that CS-Au-Ag greatly promoted wound healing compared to CS-Ag in vivo, demonstrating that CS-Au-Ag presents great potential for wound dressing, promoting wound healing.

Achieving rapid and safe control of perforating and irregular hemorrhage, defined as bleeding wounds with irregular external and internal wound shape, located deep within complex and covert hemorrhage sites, is vital to decrease the risk of mortality during prehospital treatments and surgical procedures. However, current hemostatic materials do not control hemorrhage effectively as their ability to access the bleeding source and coagulate blood is limited. Here, a biphasic Janus self-propelled hemostatic particle (MSS@CaCO 3) is prepared via uniaxial growth of flower-like calcium carbonate crystal (CaCO 3) on negatively-modified-microporous starch (MSS). The as-synthesized hemostatic particle (MSS@CaCO 3 T) is loaded with thrombin and powered by the internal component CaCO 3, with the collaborative use of protonated tranexamic acid. These particles are capable of traveling against the blood flow allowing them to access deep bleeding sites, inducing synergistic blood coagulation effects to effectively halt hemorrhaging. The self-propelling Janus hemostatic particle is sufficiently available in the deep bleeding sites of liver and femoral artery hemorrhage models, wherein the hemorrhage is rapidly controlled in ≈50 s and ≈3 min, respectively. To the authors' knowledge, this is the first attempt of controlling hemorrhage using Janus hemostatic particles with a self-propelling property.

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Trauma bleeding can be a fatal event, particularly when large quantities of blood are lost in a short time. Therefore, hemostasis has become a crucial part of emergency treatment. For...