Recent advances in materials for hemostatic management

Abstract

Trauma bleeding can be a fatal event, particularly when large quantities of blood are lost in a short time. Therefore, hemostasis has become a crucial part of emergency treatment. For...

Multiple Coordination‐Derived Bioactive Hydrogel with Proangiogenic Hemostatic Capacity for Wound Repair

“…Hemostasis is the first phase of the wound healing process, playing an essential role in wound repair. [ 40 ] Therefore, the hemostatic capability of the SGPA hydrogel was estimated using a liver hemostasis model in vivo. Figure A shows the schematic diagram of the liver hemostasis test.…”

Biomimetic peptide nanoparticles participate in natural coagulation for hemostasis and wound healing

“…N,N-Dimethylformamide (DMF) was treated with molecular sieves. 4-Methylmorpholine (NMM), trifluoroacetic acid, O-(benzotriazole-1-yl)-N,N,N′,N′-tetramethyluronium hexafluorophosphate (HBTU), 1,8-diazabicyclo [5,4,0] undec-7-ene (DBU), dimethyl sulfoxide (DMSO) and caproic acid were purchased from Aladdin. All Fmoc amino acids and Wang resins were obtained from GL Biochem (Shanghai) Ltd.…”

“…First, HUVECs were seeded in a 96-well plate for 24 h at 1-10 × 10 4 cells per well. Then, the C 6 KG peptide and the C 6 KL peptide were added to the culture media at different concentrations (5,10,20,40,80, and 160 µM). The cells treated with DMEM were taken as the control.…”

“…[1][2][3][4] Currently, various hemostatic agents have been designed for accelerating rapid hemostasis such as silicates, polysaccharides, fibrin sealants, collagen, coagulation proteins and hydrogels. [4][5][6][7] These hemostatic agents show limited efficacy in controlling severe bleeding as well as wound healing properties. Therefore, the development of hemostatic materials with inherent capabilities to promote both fast hemostasis and rapid wound healing is particularly desirable for clinical applications.…”

In situ forming injectable γ-poly(glutamic acid)/PEG adhesive hydrogels for hemorrhage control

“…Such mechanical treatments are often associated with several issues, such as their time consuming nature, scar formation, damaged connective tissues, delayed healing, and non-suitability in most emergency situations. 6,7 The past few decades have witnessed the advancement of hemostatic techniques and various forms of materials have been developed for wound management, including powders, gauzes, films, foams, sponges, hydrogels, etc. [7][8][9][10] Among them, hydrogels, especially injectable adhesive hydrogels, have received growing attention due to their advantages of excellent wound exudate adsorption capacity, retaining moisture environment, minimal tissue damage, gaseous permeability, shape adaptability to fill irregular defects 11,12 and non-compressible hemorrhage.…”