Leptospirosis is an infective disease which represents serious health and economic problems in pig raising. The disease is caused by bacteria from genus Leptospira interrogans, which has over 250 serotypes and is isolated from most animal species and also from humans in almost every country in the world. In farm conditions the disease is seldom manifested as a clinically apparent illness. More often is manifested as reduced conception rate increased abortion rate and increased birth of dead and non-vital piglets. The leptospirosis control and eradication program was made for a state owned farm with a capacity of about 1500 sows and over 30000 fattened animals per year. The farm had an on going endemic leptospirosis infection and subsequent progressive economic losses. We detected 29,80% seropositive sows and gilts in which serotypes pomona and icterhaemorrhagiae were isolated. Serologic examination of blood was performed again after program implementation, and no positive animals were found, while production and economic results were improved. The control of leptospirosis and the eradication program for a five-year period were based on detailed quantification of economics losses. Using cost-benefit analysis the necessary inputs and planned outputs were defined, and program evolution was made on the basis of net present value and benefit/cost ratio
Gumboro disease is an acute infectious disease which causes primary lesions in the Bursa Fabricii. The disease is most commonly seen in broilers between the third and sixth week of growth, and in egglaying hens up to the 18th week. In susceptible flocks the disease emerges abruptly, with high morbidity (up to 100%) and with an average mortality of 20-30%. The disease causes large economic losses in intensive poultry production. In this investigation we used the epidemiological data on Gamboro disease spreading and the extent of economic losses in broilers and egg-laying hens on a single epizootiologic region during a six-year period. Closer analysis of economic losses was performed on experimental farms. A higher prevalence of the diseases in egg-laying hens than in broilers was observed (p<0.05), while the incidence was in both groups higher during the summer period (in June and July) than during the rest of the year (p<0.05). The extent of economic losses during observed period was 11,654,336 dinars. Broilers participated in total losses with 14.76%, and egg-laying hens with 85.24%. The proposed program of Gumboro disease control in the observed epizootiological region showed economic justification (NPV = 56.277.056,84 dinars; RBC = 2.418, and RTI = 4.71 years)
From the regulatory point of view registration documentation is confirmation of quality of every part of pre-marketing production of veterinary medicine. Registration documentation also confirms the quality of given veterinary medicine during marketing authorization in Serbia. In the article, the authors gave short overview of the documentation structure and indicate the most common errors which arise during its compiling.
Krata sadr ajUvođenjem novog leka oklacitinib maleata u veterinarsku kliničku praksu napravljen je značajan pomak u lečenju alergijskog i kliničkih slučajeva atopijskog dermatitisa (posebno pratećeg svraba) kod pasa.U lečenju ovih bolesti do sada su se najčešće koristili glukokortikoidi, ciklosporin i antihistaminici. Pokazalo se da ciklosporin ima sličnu aktivnost kao i glukokortikoidi, dok je aktivnost antihistaminika slabija. Novi lek oklacitinib maleat ima antiinflamatorni i antipruritični efekt sličan onom koji izazivaju glukokortikoidi i ciklosporin, ali mu (za razliku od njih) efekt brže nastupa, što mu daje veliku prednost.Oklacitinib je imunomodulator i ima specifičan mehanizam delovanja. Deluje tako što inhibira aktivnost enzima janus kinaza (pre svega JAK1 i JAK3), od kojih zavisi funkcija proinflamatornih i pruritogenih citokina.Oklacitinib je prilično bezbedan lek, ukoliko se koristi u kraćem vremenskom periodu i u preporučenim dozama.Klju ne re i:1 Fakultet veterinarske medicine, Univerzitet u Beogradu, Srbija 2 Agencija za lekove i medicinska sredstva, Beograd, Srbija. В т ринарс и урна Р пу и Српс Veterinar Journal of Repu lic of Srps a (Ба а Лу а-Banja Lu a) Во /Vol VII r/NoVitomir Ćupić i sar.: Novi lek u veterinarskoj kliničkoj praksi oklacitinib maleat A stractThe introduction of a new drug oclacitinib maleate in veterinary clinical practice, has been made a big step forward in the treatment of allergic and clinical cases of atopic dermatitis (especially a accompanying pruritus) in dogs.So far glucocorticoids, cyclosporine, and antihistamines were most commonly used in the treatment of the above mentioned diseases. It has been shown that cyclosporine has a similar activity, as glucocorticosteroids, while the activity of antihistamines is weaker. New drug oclacitinib maleate has anti-inflammatory and antipruritic effect similar to that caused by glucocorticoids and cyclosporine, but (unlike them) it achieves more rapidly effect, which gives him a huge advantage.Oclacitinib is an immunomodulator and has a specific mechanism of action. It inhibits the activity of the Janus kinase enzymes (primarily JAK1 and JAK3), from which the function of pro-inflammatory and pruritic cytokines depends.Oclacitinib is a uite safe drug, if used in a shorter period of time, at the recommended doses.
Period pre partusa kod visoko mlečnih krava je praćen povećanim zahtevima za energijom koja se ne može obezbediti hranom, pa krave ulaze u negativan bilans energije koji dovodi do različitih metaboličkih poremećaja. Dodavanjem mikroelemenata kravama u hranu postiže se poboljšanje zdravlja krava. Selen kao mikroelement ima esencijalan značaj u pravilnom funkcionisanju mlečne žlezde krava. Vrednosti koncentracije selena u mlečnom serumu kod visoko-mlečnih krava su 2-60 µg/l. Eksperimentalno je utvrđeno da aplikacija selena pozitivno utiče smanjenje broja somatskih ćelija u mleku. Iz dobijenih rezultata može se uočiti da dodavanje suplemenata selena u hranu krava tokom perioda rane laktacije može pozitivno da utiče na zdravlje mlečne žlezde visko produktivnih krava, a samim tim i na njihovo zdravstveno stanje i proizvodnju mleka.
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