Leptospirosis is an infective disease which represents serious health and economic problems in pig raising. The disease is caused by bacteria from genus Leptospira interrogans, which has over 250 serotypes and is isolated from most animal species and also from humans in almost every country in the world. In farm conditions the disease is seldom manifested as a clinically apparent illness. More often is manifested as reduced conception rate increased abortion rate and increased birth of dead and non-vital piglets. The leptospirosis control and eradication program was made for a state owned farm with a capacity of about 1500 sows and over 30000 fattened animals per year. The farm had an on going endemic leptospirosis infection and subsequent progressive economic losses. We detected 29,80% seropositive sows and gilts in which serotypes pomona and icterhaemorrhagiae were isolated. Serologic examination of blood was performed again after program implementation, and no positive animals were found, while production and economic results were improved. The control of leptospirosis and the eradication program for a five-year period were based on detailed quantification of economics losses. Using cost-benefit analysis the necessary inputs and planned outputs were defined, and program evolution was made on the basis of net present value and benefit/cost ratio
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