Patients seeking medical attention for respiratory infections were investigated with serology and culture for Chlamydia pneumoniae to investigate the prevalence of C. pneumoniae in a specific geographical area and its association with respiratory disease. Evidence for C. pneumoniae infection was found in approximately 25% of cases. 71% of patients with C. pneumoniae had symptoms from the lower respiratory tract as compared to 29% of the others. We conclude that C. pneumoniae can be a major cause of acute bronchitis.
12 patients with longstanding throat symptoms, who were also positive by PCR (polymerase chain reaction) for Chlamydia pneumoniae were selected for a longitudinal study to determine whether C. pneumoniae is an aetiological agent for chronic pharyngitis. Specimens for culture and PCR detection of C. pneumoniae were taken from the retropharyngeal wall and blood specimens were taken for serology. Biopsies were taken from the mucosal membrane of the retropharyngeal wall for histological and immunohistochemical studies. C. pneumoniae was cultured from 4 cases. 10 patients had specific humoral antibodies to C. pneumoniae and 9 had high and increasing specific antibody titres to C. pneumoniae suggesting ongoing infection. The organism was demonstrated in the tissue from the retropharyngeal mucosal membrane by immunohistochemistry in 9 patients. The findings suggest that C. pneumoniae may be an aetiological agent for chronic pharyngitis.
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