Objective:
Various histological grading of oral squamous cell carcinoma has been contributed to the literature at different periods, but the reliability of such grading systems is controversial. This study attempted to measure the efficacy of Bryne's parameters on the full thickness of incisional biopsies which are representative of the original lesion with the proven molecular malignancy markers P53 and Ki67.
Materials and Methods:
One hundred incisional biopsy specimens of oral squamous cell carcinoma were obtained and histologically graded according to Broder's grading system. The same was graded using Bryne's parameters on full thickness of obtained incision sample. Immunohistochemistry was carried out for both p53 and Ki67.
Results:
We found a high discrepancy in the grading of lesions with Broader as well as Bryne grading parameters within the same lesion. When compared with the molecular expression percentages of p53 and Ki67, highly significant correlation was found in Bryne's parameters (Pearson Chi-square,
P
value 0.000) in incisional biopsies than Broder's.
Conclusion:
The use of parameters by Bryne on invasive front of excision biopsies can provide significant grading on incisional biopsies which are more comparable to the molecular behavior of tumor given by the p53 and Ki67 expression.
The present study was conducted with an objective to assess nutritional status of school going children. The study was conducted in village Hurda of Hurdapanchayatsamiti of Bhilwara district of Rajasthan. Total 120 school going children (15 girls and 15 boys from each school) were selected. Nutritional status of the subjects was assessed by using anthropometric measurements (height and weight), clinical assessment and dietary recall method. All respondents were vegetarian. The height and weight of respondents was lower than reference value. Severely wasted (44.43%), Severely stunted (32.2) according to Waterlow classification. Gomez classification revealed (60%) respondent's was severely malnourished. According to BMI for age z-score severely undernourished was found 33.33 per cent. In Clinical assessment of respondent's revealed equal number of respondents was in normal and poor appearance (41.66%). Diffused pigmentation in children were (25%), lack of luster were (16.66%), Pale conjunctiva were (23.33), Cheilosis (19.16). Dietary intake of respondents was substantially inadequate (<50%) in all food groups whereas intake of sugar was marginally adequate (83%) dietary intake was lower than recommended dietary intake (RDI). The mean nutrient intake was significantly lower than recommended dietary allowances .Intake of protein of respondents was 81 per cent of RDA.
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