Cytotoxic Role of Chlorogenic Acid on Oral Squamous Cell Carcinoma Cell Line

Sharma, Gitika; Kamboj, Mala; Narwal, Anjali; Bhardwaj, Rashmi; Yadav, Pooja

doi:10.1007/s12070-021-02395-1

Cited by 6 publications

(5 citation statements)

References 19 publications

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“…The great majority of the 60 included studies were in vitro ( n = 51, 85.0%), with a smaller portion ( n = 9, 15.0%) consisting of in vivo or in silico studies. Six (10.0%) of studies incorporated multiple study designs 20–24 . This distribution aligns with our initial research question and search strategy.…”

Section: Resultssupporting

confidence: 56%

“…Our results indicate that flavonoids, especially quercetin and EGCG, were the most represented in the literature, followed by phenols (Table 1). From our analysis, quercetin was found to demonstrate anti‐proliferative effects via antioxidant activity and the induction of apoptosis in certain oral cancer cell lines 22,35–40 . Although it is unclear why there is an emphasis on quercetin and EGCG in the literature, it may be due to an increased potential in these constituents to affect cancer development or progression.…”

Section: Constituents and Oscc Development Or Progressionmentioning

confidence: 88%

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Can a cup a day keep cancer away? A systematic review exploring the potential of coffee constituents in preventing oral squamous cell carcinoma

Deng,

Misra,

Vilash

et al. 2023

J Oral Pathology Medicine

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BackgroundCoffee is one of the most consumed beverages in the world. Containing an abundance of bioactive molecules including polyphenols and flavonoids, the constituents of this beverage may exert antiproliferative, antioxidant and anti‐inflammatory effects.MethodsWe conducted a systematic review to summarise the available evidence on the anticancer effects of coffee constituents and their potential therapeutic use for oral squamous cell carcinoma (OSCC). Studies were identified through a comprehensive search of OVID MEDLINE, OVID EMBASE and Web of Science, including articles from any year up to 15 May 2023.ResultsOf the 60 reviewed papers, 45 were in vitro, 1 was in silico and 8 were in vivo exclusively. The remaining studies combined elements of more than one study type. A total of 55 studies demonstrated anti‐proliferative effects, whilst 12 studies also investigated migration and invasion of neoplastic cells. The constituents studied most frequently were quercetin and epigallocatechin gallate (EGCG), demonstrating various cytotoxic effects whilst also influencing apoptotic mechanisms in cancer cell lines. Dose‐dependent responses were consistently found amongst the studied constituents.ConclusionWhilst there was heterogeneity of study models and methods, consistent use of specific models such as SCC25 for in vitro studies and golden hamsters for in vivo studies enabled relative comparability. The constituents of coffee have gained significant interest over the last 30 years, particularly in the last decade, and present an area of interest with significant public health implications. Currently, there is a paucity of literature on utilization of active coffee constituents for the therapeutic treatment of oral cancers.

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Section: Resultssupporting

confidence: 56%

Section: Constituents and Oscc Development Or Progressionmentioning

confidence: 88%

Can a cup a day keep cancer away? A systematic review exploring the potential of coffee constituents in preventing oral squamous cell carcinoma

Deng,

Misra,

Vilash

et al. 2023

J Oral Pathology Medicine

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“…It has been reported in the literature that these five ingredients possess anti-cancer properties. Specifically, syringic acid targets glioblastoma, gastric cancer, and ovarian teratoma cancer [35][36][37]; kirenol exhibits efficacy against thyroid cancer, cancer, and myeloid leukemia [38][39][40]; chlorogenic acid shows potential against pancreatic cancer, colorectal cancer, ovarian cancer, and oral squamous carcinoma [41][42][43][44]; p-coumaric acid demonstrates activity on epidermoid carcinoma, colorectal cancer, osteosarcoma, and glioblastoma [45][46][47][48]; syringaldehyde is effective against breast cancer [49]. However, the impact of these ingredients on liver cancer needs further exploration.…”

Section: Discussionmentioning

confidence: 99%

<em>Siegesbeckia orientalis</em> Suppresses Growth and Migration through Apoptosis and Inhibition of Matrix Metalloproteinases Expression on Hepatoma in Mice

Chen,

Houng,

Chang

et al. 2024

Preprint

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This study investigated the inhibitory effect of Siegesbeckia orientalis ethanolic extract (SOE) on growth and metastasis of hepatic tumors in C57BL/6JNarl mice, which is the model of tumor-igenesis induced by subcutaneous injection of Hepa1-6 murine hepatoma cells on the back of mice. Feeding 25 mg SOE/kg BW daily for 14 days effectively reduced the hepatoma weight in tu-mor-bearing mice by 59.7%. SOE intervention reduced the expression of anti-apoptotic Bcl-2 gene in tumor tissue by 48.5% and down-regulated the antioxidant system, by reducing the gene ex-pression of catalase (48.0%), glutathione peroxidase (46.3%), and superoxide dismutase (32.0%). In addition, SOE intervention increased the production of ROS by 21.4%, and the gene expression of pro-inflammatory cytokines TNF-α, IL-1β, and IL-6 by 135.3%, 179.3% and 91.7%, respectively, indicating that SOE intervention promoted the acute inflammatory response. Results of H&E staining analysis showed that SOE had the ability to inhibit angiogenesis in tumor tissue. Fur-thermore, SOE treatment inhibited the expression of migration-related genes, such as MMP-2, MMP-7, MMP-9 and β-catenin, and the inhibition rates were 24.8%, 27.4%, 10.4% and 21.9%, respectively. These results imply that SOE had the ability to suppress tumor metastasis. On the other hand, SOE intervention decreased the serum contents of inflammatory cytokines, such as TNF-α, IL-1β and IL-6 by 27.4%, 30.4%, and 30.7%, respectively, indicating that SOE intervention has an anti-inflammatory effect on normal tissues of mice. Since SOE intervention had no signif-icant effect on liver and kidney weights, and no mice died throughout the experiment, it shows that it is safe to feed SOE under this experimental condition. Based on the above results, SOE has a great potential to be used in the treatment of hepatoma.

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“…Studies have highlighted its positive effects on neuroprotection, cardiovascular health, gastrointestinal health, kidney protection, liver protection, and the regulation of lipid metabolism [ 8 , 9 , 10 ]. Moreover, CGA has shown potential in suppressing the growth of tumors across several types of cancer, including colon, breast, lung, oral squamous cell carcinoma, and chronic myeloid leukemia [ 11 , 12 , 13 ]. However, research on the potential anti-tumor effects of CGA on CCA has been limited.…”

Section: Introductionmentioning

confidence: 99%

Chlorogenic Acid as a Potential Therapeutic Agent for Cholangiocarcinoma

Liang,

Wen,

Zhang

et al. 2024

Pharmaceuticals

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Chlorogenic acid (CGA) has demonstrated anti-tumor effects across various cancers, but its role in cholangiocarcinoma (CCA) remains unclear. Our study revealed CGA’s potent anti-tumor effects on CCA, significantly suppressing cell proliferation, migration, colony formation, and invasion while inhibiting the epithelial–mesenchymal transition. CGA induced apoptosis, modulated cell cycle progression, and exhibited a stable binding affinity to AKR1B10 in CCA. AKR1B10 was highly expressed in RBE cells, and CGA treatment reduced AKR1B10 expression. Knocking out AKR1B10 inhibited the proliferation of RBE cells, whereas the overexpression of AKR1B10 promoted their proliferation. Additionally, CGA suppressed the proliferation of RBE cells with AKR1B10 overexpression. Mechanistically, AKR1B10 activated AKT, and CGA exerted its inhibitory effect by reducing AKR1B10 levels, thereby suppressing AKT activation. Furthermore, CGA facilitated the polarization of tumor-associated macrophages towards an anti-tumor phenotype and enhanced T-cell cytotoxicity. These findings underscore CGA’s potential as a promising therapeutic agent for CCA treatment.

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Cytotoxic Role of Chlorogenic Acid on Oral Squamous Cell Carcinoma Cell Line

Cited by 6 publications

References 19 publications

Can a cup a day keep cancer away? A systematic review exploring the potential of coffee constituents in preventing oral squamous cell carcinoma

Can a cup a day keep cancer away? A systematic review exploring the potential of coffee constituents in preventing oral squamous cell carcinoma

<em>Siegesbeckia orientalis</em> Suppresses Growth and Migration through Apoptosis and Inhibition of Matrix Metalloproteinases Expression on Hepatoma in Mice

Chlorogenic Acid as a Potential Therapeutic Agent for Cholangiocarcinoma

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