Kanker payudara merupakan jenis kanker yang umumnya diderita oleh wanita. Obat-obatan kemoterapeutik yang ada, memiliki efek samping dengan merusak sel sehat penderita. Penelitian dan penemuan phytomedicine diharapkan dapat dikembangkan dan digunakan sebagai obat kanker yang efektif dengan efek samping yang minimal. Tanaman Sphagneticola trilobata (L.) J.F Pruski merupakan salah satu tanaman obat yang belum tereksplorasi secara luas khasiatnya. Tujuan penelitian ini adalah mengembangkan potensial sitotoksik dari Sphagneticola trilobata sebagai agen anti kanker untuk menghambat mekanisme molekuler sel kanker payudara secara invivo. Pada penelitian ini mencit dibagi menjadi tiga kelompok yakni (a) kelompok kontrol, (b) kelompok perlakuan mencit yang diinduksi 7,12 Dimetilbenz(a)antrasena (DMBA), dan (c) kelompok perlakuan DMBA+ekstrak S.trilobata. Gambaran mikroskopik payudara mencit yang diinduksi DMBA menunjukkan adanya hiperplasia sel epitel kolumnar duktus laktiferi (lebih dari 4 lapis); sedangkan payudara mencit yang diberikan ekstrak S.trilobata setelah diinduksi dengan DMBA menunjukkan hiperplasia sel epitel yang lebih ringan (kurang dari 4 lapis). Pembuktian ilmiah S.trilobata sebagai agen anti kanker diperkuat dengan data penurunan kadar ALT dan kreatinin pada mencit yang diinduksi DMBA. Secara keseluruhan, hasil penelitian ini menyimpulkan bahwa S.trilobata sebagai phytomedicine memiliki fungsi anti tumor dan hepatoprotektor
Low birthweight babies are babies with a birth weight of 1,500 grams to less than 2,500 grams. Low birthweight babies are the cause of increase in babies’ mortality (death) and morbidity (pain). One of the primary risk factors of low birthweight babies is poor pregnant mother’s nutrition. Iron can provide a reserve or storage of nutrition that is very much needed by pregnant mothers to prevent anemia and maintain optimal growth of fetuses. The occurrence of low birthweight babies in Aceh Barat Regency is still very high. The design of this research was observational with an intervention of providing iron for 90 days to pregnant mothers and nutritional guidance for pregnant mothers in the effort of reducing the prevalence of low birthweight babies. The research was done in 10 villages from 3 rural sub-districts that contribute to high rates of low birthweight babies in Aceh Barat Regency, with 146 pregnant mothers. The results of the research showed that the application of the informal guidance strategy in a non-formal setting accompanied with discussions among family members and guidance targets resulted in 69.2% of guidance targets becoming motivated to consume Fe tablets and maintain eating patterns, while guidance targets that have been motivated yet did not consume Fe tablets and maintain eating patterns gave low income of guidance and Fe tablets were observed for 3 months; the result was 13 mothers (86.7%) gave birth to babies of normal weight and 2 mothers (13,3%) gave birth to underweight babies. The application of the guidance strategy in the effort to reduce the occurrence of low birthweight babies, from the results of this research, requires commitment from the Department of Health to provide suitable funds, facilities, and infrastructure to provide services to pregnant mothers, and commitment of all health officials in particular village nurses and health cadres, as well as involving the husband in the role to maintain a healthy pregnancy.
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