In this study, comparison of preliminary phytochemical screening of Wedeliabiflorawas conducted using the n-hexane and ethyl acetate solvents extracts. The W.biflora samples were grouped into flowers andleaves. The different solvents of flowers extracts exhibited secondary compound viz. flavonoid, alkaloid, fenol, tannin, steroid, and saponin. While the extracts of leaves revealed flavonoid, alkaloid, fenol, tannin and steroid without saponin. Thus, the present of various bioactive components in the W. bifloraextract might bepotential for responsible on the pharmacological activities including antifungi, antibacterial, antioxidant, anti-inflammatory and anticancer.
This study evaluated antioxidant and cytotoxicity of methanol extract from flowers of Sphagneticola trilobata (L.) J.F. Pruski. Phytochemical Screening of the flowers exhibited the presence of alkaloid, flavonoid, phenol, saponin, steroid and absent of tannin. The flowers extract also showed good source of antioxidant with an IC50 value of 19.072 μg/ml which was categorized in the range of strong antioxidant activity (<150 ppm). Cytotoxic activity of the flowers against HeLa cell line was found to 331.287 (LC50) or 83% inhibition. The results might suggest/support the flower of S,trilobata as source of natural antioxidant. However, further study about in vivo antioxidant and lethal dose of this sample are recommended.
The utilization of natural compounds as therapeutic agents to treat pancreatic cancer has recently focused on natural drug research. Calotropis gigantea has long been believed to be a medicinal plant that helps in treating various diseases. The bioactive compounds 9-metoxipinoresinol and isoliquiritigenin isolated from C. gigantea leaves are proven to act as therapeutic agents by inhibiting the cancer cell growth of Panc-1 cells. This study aimed to screen the potential molecular inhibition mechanisms of 9-metoxipinoresinol and isoliquiritigenin against pancreatic cancer development in-silico. We analyzed the activity of the aforementioned two compounds as inhibitors of several proteins that play a role in the growth of pancreatic cancer cells, such as GCNT3, GOT1, c-Met, PPARγ, BUB1, and NF-κβ, through molecular docking investigation. Our data suggested that 9-metoxipinoresinol and isoliquiritigenin were able to have well interaction with the target proteins, in which the predicted affinity energy ranged between -6.8 and 8.7 kcal/mol. The docking scores of 9-metoxipinoresinol and isoliquiritigenin were higher than the standard drug used (gemcitabine). Based on the binding affinity energy, GCNT3 and BUB1 are potentially to be used as target molecules for cancer therapy using 9-metoxipinoresinol and isoliquiritigenin, respectively.
Hidroponik merupakan cara bercocok tanam dengan menggunakan media larutan air dan atau media selain tanah. Salah satu media pengganti tanah adalah limbah tebu. Bagase (limbah tebu) merupakan residu yang diperoleh dari proses penggilingan tanaman tebu (Saccharum oficiarum). Tujuan dari program pengabdian kepada masyarakat (PKM) ini adalah memberi pengetahuan dan keterampilan pada masyarakat Sidorejo untuk bercocok tanam menggunakan sistem hidroponik dengan memanfaatkan limbah tebu menjadi media tanam hidroponik sebagai upaya pengelolaan lingkungan berkelanjutan. Sasaran utama program PKM ini adalah kelompok PKK Gampong Sidorejo. Metode yang digunakan meliputi ceramah, praktik langsung, dan diskusi. Hasil kegiatan memyimpulkan bahwa: 1) Pengetahuan peserta tentang budi daya hidroponik menggunakan limbah tebu meningkat sekitar 20%; 2) Kegiatan ini telah memberi manfaat bagi masyarakat Sidorejo, khususnya ibu-ibu PKK dengan meningkatnya keinginan peserta untuk mengikuti pelatihan serupa sekitar 98%; dan 3) Bertanam sistem hidroponik dapat dijadikan sarana penyaluran hobi, kesehatan, dan dapat dikembangkan menjadi skala bisnis.
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