No abstract

No abstract

Bryophytes comprise of the mosses, liverworts, and hornworts. Cryphaea heteromalla, (Hedw.) D. Mohr, is a non-vascular lower plant belonging to mosses group. To the date, the most chemically characterized species belong to the liverworts, while only 3.2% and 8.8% of the species belonging to the mosses and hornworts, respectively, have been investigated. In this work, we present Folin–Ciocalteu and oxygen radical absorbance capacity (ORAC) data related to crude extracts of C. heteromalla obtained by three different extraction solvents: pure water (WT), methanol:water (80:20 v/v) (MET), and ethanol:water (80:20 v/v) (ETH). The water extract proved to be the best solvent showing the highest content of biophenols and the highest ORAC value. The C. heteromalla-WT extract was investigated by HPLC-TOF/MS (High Performance Liquid Chromatography-Time of Flight/Mass Spectrometry) allowing for the detection of 14 compounds, five of which were phenolic compounds, derivatives of benzoic, caffeic, and coumaric acids. Moreover, the C. heteromalla WT extract showed a protective effect against reactive oxygen species (ROS) generation induced by tert-butyl hydroperoxide (TBH) on the murine NIH-3T3 fibroblast cell line.

Oxidative stress and mitochondrial dysfunction play an important role in the onset of neurodegenerative diseases; thus, the antioxidant use could be a promising preventive or therapeutic intervention. The food and agricultural industries generate huge quantities of by-products rich in biophenolic compounds. If, on the one hand, they represent a serious environmental problem, on the other hand, are valuable natural sources of antioxidants. In the present work, the total phenolic content and the antioxidant power of the wastewater derived from the production of four Sicilian extra virgin olive oils are shown. Four biophenols, hydroxytyrosol and tyrosol alcohols and caffeic acid (CA) and p-coumaric acids, were identified and quantified and their antioxidant ability determined. Their effects in counteracting Abeta 1-42 oligomer oxidative damage in LAN5 cell culture were investigated. Results indicated that CA was the most effective compound in counteracting the cell damages induced by Abeta 1-42 oligomers. El contenido valioso de aguas residuales producidas por almazaras: el efecto protector de la fracción antioxidante en cultivos celulares RESUMEN El estrés oxidativo y la disfunción mitocondrial juegan un rol importante en el comienzo de ciertas enfermedades neurodegenerativas; en estos casos, el uso de antioxidantes puede ser una intervención preventiva o terapéutica prometedora. Las industrias alimentarias y agrícolas producen enormes cantidades de subproductos ricos en compuestos biofenólicos. Si bien por un lado representan un grave problema ambiental, por el otro constituyen valiosas fuentes naturales de antioxidantes. En el presente estudio se analizan el contenido fenólico total y el poder antioxidante de las aguas residuales (WW) derivadas de la producción de cuatro aceites de oliva virgen extra (AOVE) de Sicilia. Para el efecto, Se identificaron y cuantificaron cuatro biofenoles, alcoholes hidroxitirosol (HT) y tirosol (TY), además de ácidos cafeico (CA) y p-cumárico (CU), y se determinó su capacidad antioxidante. Asimismo, se investigaron sus efectos para contrarrestar el daño oxidativo provocado por el oligómero Abeta 1-42 en cultivos celulares LAN5, constatándose que el CA fue el más efectivo para contrarrestar el daño celular inducido por oligómeros Abeta 1-42 .