Agarose/κ-carrageenan-based hydrogel film enriched with natural plant extracts for the treatment of cutaneous wounds

Ditta, Lorena Anna; Rao, Estella; Provenzano, Fiorenza; Lozano-Sánchez, Jesús; Santonocito, Radha; Passantino, Rosa; Costa, Maria Assunta; Sabatino, Maria Antonietta; Dispenza, Clelia; Giacomazza, Daniela; Biagio, Pier Luigi San; Lapasin, Romano

doi:10.1016/j.ijbiomac.2020.08.170

Cited by 29 publications

(18 citation statements)

References 68 publications

(84 reference statements)

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“…It is worth noting that in recent years there has been a trend showing the interest of researchers in modifying hydrogels intended to wound healing also with medicinal substances of natural origin, mainly extracted from plants [22]. For example, it has been shown that Cryphaea heteromalla aqueous extract in the hydrogel film may prevent excess oxidative stress generation during wound healing [23]. In turn, Ciolacu et al incorporated lignin into the hydrogel and produced hydrogel structures with a higher drug release rate; however, Wang and Chen successfully tested the influence of the addition of cellulose nanowhiskers to cellulose physical gels resulting in the more steady release of the protein.…”

Section: Introductionmentioning

confidence: 99%

Impact of the Type of Crosslinking Agents on the Properties of Modified Sodium Alginate/Poly(vinyl Alcohol) Hydrogels

Bialik-Wąs

Królicka

2021

Molecules

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Here, we report on studies on the influence of different crosslinking methods (ionic and chemical) on the physicochemical (swelling ability and degradation in simulated body fluids), structural (FT-IR spectra analysis) and morphological (SEM analysis) properties of SA/PVA hydrogels containing active substances of natural origin. First, an aqueous extract of Echinacea purpurea was prepared using a Soxhlet apparatus. Next, a series of modified SA/PVA-based hydrogels were obtained through the chemical crosslinking method using poly(ethylene glycol) diacrylate (PEGDA, Mn = 700 g/mol) as a crosslinking agent and, additionally, the ionic reaction in the presence of a 5% w/v calcium chloride solution. The compositions of SA/PVA/E. purpurea-based hydrogels contained a polymer of natural origin—sodium alginate (SA, 1.5% solution)—and a synthetic polymer—poly(vinyl alcohol) (PVA, Mn = 72,000 g/mol, 10% solution)—in the ratio 2:1, and different amounts of the aqueous extract of E. purpurea—5, 10, 15 or 20% (v/v). Additionally, the release behavior of echinacoside from the polymeric matrix was evaluated in phosphate-buffered saline (PBS) at 37 °C. The results indicate that the type of the crosslinking method has a direct impact on the release profile. Consequently, it is possible to design a system that delivers an active substance in a way that depends on the application.

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Section: Introductionmentioning

confidence: 99%

Impact of the Type of Crosslinking Agents on the Properties of Modified Sodium Alginate/Poly(vinyl Alcohol) Hydrogels

Bialik-Wąs

Królicka

2021

Molecules

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“…The conditions of extraction and purification processes influence the polysaccharide properties [ 51 , 52 ] and the resulting polysaccharide-derived hydrogels. However, the effect of polysaccharide structure and composition on hydrogel properties has not been widely studied due to the fact that for the synthesis of hydrogel, purchased algal polysaccharides are often used rather than obtaining the polysaccharides from extraction and purification [ 7 , 53 , 54 ]. A schematic overview for algal polysaccharide extraction is presented in Figure 1 .…”

Section: Algae-based Polysaccharides Extractionmentioning

confidence: 99%

“…Thus, biocompatibility evaluation is an important indicator of the safety of drug delivery systems and scaffolds. The assessment applied to polysaccharides-based hydrogels usually involves chemical analysis, tissue cultures, and animal tests [ 7 , 8 , 249 , 250 , 251 , 252 , 253 , 254 , 255 ]. However, risk-free drug delivery systems do not exist, so those tests aim to screen systems or materials with maximum benefits and minimum risks.…”

Section: Performance Of Seaweed Polysaccharide-based Hydrogelsmentioning

confidence: 99%

“…In 1960, Wichterle and Lim published a landmark article in the scientific journal, Nature , in which synthetic poly(2-hydroxyethyl methacrylate) gels were designed as soft contact lenses [ 4 ]. These promising materials have been widely applied in the fields of biotechnology, including drug delivery [ 1 , 2 ], tissue engineering [ 5 , 6 ], wound dressing [ 7 , 8 ], agrochemicals application [ 9 , 10 ], separation [ 11 , 12 ], food packaging [ 13 , 14 ], and cosmetics and personal care products [ 15 , 16 ]. The hydrophilic polymer structures can be designed using physical and/or chemical crosslinking methods.…”

Section: Introductionmentioning

confidence: 99%

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Algal Polysaccharides-Based Hydrogels: Extraction, Synthesis, Characterization, and Applications

Lin

Jiao²,

Kermanshahi-pour

2022

Marine Drugs

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Hydrogels are three-dimensional crosslinked hydrophilic polymer networks with great potential in drug delivery, tissue engineering, wound dressing, agrochemicals application, food packaging, and cosmetics. However, conventional synthetic polymer hydrogels may be hazardous and have poor biocompatibility and biodegradability. Algal polysaccharides are abundant natural products with biocompatible and biodegradable properties. Polysaccharides and their derivatives also possess unique features such as physicochemical properties, hydrophilicity, mechanical strength, and tunable functionality. As such, algal polysaccharides have been widely exploited as building blocks in the fabrication of polysaccharide-based hydrogels through physical and/or chemical crosslinking. In this review, we discuss the extraction and characterization of polysaccharides derived from algae. This review focuses on recent advances in synthesis and applications of algal polysaccharides-based hydrogels. Additionally, we discuss the techno-economic analyses of chitosan and acrylic acid-based hydrogels, drawing attention to the importance of such analyses for hydrogels. Finally, the future prospects of algal polysaccharides-based hydrogels are outlined.

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“…Such molecules are usually polyphenols and their derivatives, but also other compounds, from both natural and synthetic sources, have been employed with remarkable results. Ceria [79], curcumin [80], hydroxycinnamic acid derivatives, such as p-coumaric and ferulic acids [81], tannic acid [82], propolis [83], natural plant extracts [84][85][86], anthocyanins [87] and many other phytochemicals within nanocomposites have been tested for their ROS scavenging activities with relevant effects, especially in the case of diabetic chronic wounds, where over-production of ROS can impair angiogenesis and results in continuous inflammation [88][89][90].…”

Section: Antioxidant Propertiesmentioning

confidence: 99%

Nanomaterials in Skin Regeneration and Rejuvenation

Bellu

Medici

Coradduzza

et al. 2021

IJMS

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Skin is the external part of the human body; thus, it is exposed to outer stimuli leading to injuries and damage, due to being the tissue mostly affected by wounds and aging that compromise its protective function. The recent extension of the average lifespan raises the interest in products capable of counteracting skin related health conditions. However, the skin barrier is not easy to permeate and could be influenced by different factors. In the last decades an innovative pharmacotherapeutic approach has been possible thanks to the advent of nanomedicine. Nanodevices can represent an appropriate formulation to enhance the passive penetration, modulate drug solubility and increase the thermodynamic activity of drugs. Here, we summarize the recent nanotechnological approaches to maintain and replace skin homeostasis, with particular attention to nanomaterials applications on wound healing, regeneration and rejuvenation of skin tissue. The different nanomaterials as nanofibers, hydrogels, nanosuspensions, and nanoparticles are described and in particular we highlight their main chemical features that are useful in drug delivery and tissue regeneration.

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Agarose/κ-carrageenan-based hydrogel film enriched with natural plant extracts for the treatment of cutaneous wounds

Cited by 29 publications

References 68 publications

Impact of the Type of Crosslinking Agents on the Properties of Modified Sodium Alginate/Poly(vinyl Alcohol) Hydrogels

Impact of the Type of Crosslinking Agents on the Properties of Modified Sodium Alginate/Poly(vinyl Alcohol) Hydrogels

Algal Polysaccharides-Based Hydrogels: Extraction, Synthesis, Characterization, and Applications

Nanomaterials in Skin Regeneration and Rejuvenation

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