Bioactive compounds from extra virgin olive oils: Correlation between phenolic content and oxidative stress cell protection

Presti, Giovanni; Guarrasi, Valeria; Gulotta, Eleonora; Provenzano, Fiorenza; Provenzano, Alessia; Giuliano, Salvatore; Monfreda, Maria; Mangione, Maria Rosalia; Passantino, Rosa; Biagio, Pier Luigi San; Costa, Maria Assunta; Giacomazza, Daniela

doi:10.1016/j.bpc.2017.09.002

Cited by 39 publications

(31 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This data could be supported by the observed reduction trend of oxidative stress (OS); in fact, the latter plays a key role in the progression of the CKD because OS is related to CKD complications like arterial hypertension, low-grade chronic inflammation, and anemia [ 25 , 26 ]. The OS reduction observed confirms previous studies [ 27 , 28 , 29 , 30 ] such as the CMPs of EVOO play a key role in the mechanisms that favor the induction of antioxidant activity [ 31 , 32 , 33 ].…”

Section: Resultssupporting

confidence: 88%

Potential Beneficial Effects of Extra Virgin Olive Oils Characterized by High Content in Minor Polar Compounds in Nephropathic Patients: A Pilot Study

et al. 2020

View full text Add to dashboard Cite

Extra virgin olive oil (EVOO) is a lipid food, which constitutes a pillar of the Mediterranean diet. A high number of scientific data have demonstrated that it exerts a variety of beneficial effects on human health due to its peculiar chemical composition including fatty acids (98–99%) and other active compounds even if found in a very low percentage (1–2%). Among them, minor polar compounds (MCPs), represented mainly by phenolic compounds, are relevant for their healthy properties, as stated by the European Food Safety Authority’s (EFSA) claims. In this paper, we described the results obtained from a pilot in vivo study, focused for the first time on the evaluation of the possible beneficial effects of two EVOOs on chronic kidney disease (CKD) patients after the consumption of 40 mL per day for 9 weeks. The selected EVOOs, traced in the production chain, and characterized by High-Performance Liquid Chromatography (HPLC-DAD-MS) analysis, resulted rich in MCPs and satisfied the EFSA’s claim for their content of hydroxytyrosol and derivatives. The results obtained by this in vivo study appear to highlight the potential beneficial role in CKD patients of these EVOOs and are promising for future studies.

show abstract

Section: Resultssupporting

confidence: 88%

Potential Beneficial Effects of Extra Virgin Olive Oils Characterized by High Content in Minor Polar Compounds in Nephropathic Patients: A Pilot Study

et al. 2020

View full text Add to dashboard Cite

show abstract

“…[43][44][45] Olive oil contains beneficial substances such as polyphenols and monounsaturated fatty acids that have a positive effect on oxygenic metabolism. [46][47][48][49] Other substances, such as vitamin C in fruits and vegetables, have a positive effect on the protection against lipoperoxidation. 50,51 The aim of the present study is to analyze the situation of oxygenic metabolism in obesity and the endogenous and exogenous cytotoxicity induced by ROS in Wistar rats fed with liquid diets based on olive oil and supplemented with vitamin C for 30 days.…”

Section: Introductionmentioning

confidence: 99%

Oxygenic metabolism in nutritional obesity induced by olive oil. The influence of vitamin C

et al. 2019

View full text Add to dashboard Cite

show abstract

“…The molecule 2′,7′-dichlorodihydrofluorescein diacetate (DCFH-DA) can freely enter cells through the cell membrane and are hydrolyzed to DCFH by cellular esterases. DCFH cannot penetrate the cell membrane, and intracellular ROS can oxidize non-fluorescent DCFH to produce fluorescent DCF (Presti et al., 2017 ). Therefore, the detection of DCF fluorescence can be used to estimate the ROS levels in cells.…”

Section: Resultsmentioning

confidence: 99%

Anti-GPC3 antibody-modified sorafenib-loaded nanoparticles significantly inhibited HepG2 hepatocellular carcinoma

Tang

Chen

et al. 2018

Drug Delivery

View full text Add to dashboard Cite

Sorafenib (SFB) has improved the treatment of hepatocellular carcinoma (HCC) and has fewer severe side effects than other agents used for that purpose. However, due to a lack of tumor-specific targeting, the concentration of the drug in tumor tissue cannot be permanently maintained at a level that inhibits tumor growth. To overcome this problem, we developed a novel SFB-loaded polymer nanoparticle (NP). The NP (a TPGS-b-PCL copolymer that was synthesized from ε-caprolactone and d-α-tocopheryl polyethylene glycol 1000 succinate (TPGS) via ring-opening polymerization) contains Pluronic P123 and SFB, and its surface is modified with anti-GPC3 antibody to produce the polymer nanoparticle (NP-SFB-Ab). The Ab-conjugated NPs had higher cellular uptake by HepG2 cells than did non-antibody-conjugated SPD-containing nanoparticles (NP-SFB). The NP-SFB-Ab also displayed better stability characteristics, released higher levels of SFB into cell culture medium, and was more cytotoxic to tumor cells than was non-targeted NP-SFB and free SFB. The NP-SFB-Ab downregulated expression of the anti-apoptosis molecule MCL-1, which led to polymerization of Bax and Bak in mitochondrial cytosol. The NP-SFB-AB also promoted the mitochondrial release of cytochrome C, resulting in cellular apoptosis. Moreover, the NP-SFB-Ab significantly inhibited the growth of HepG2 xenograft tumors in nude mice without producing obvious side effects. These findings suggest that NP-SFB-Ab is a promising new method for achieving targeted therapy of HCC.

show abstract

Bioactive compounds from extra virgin olive oils: Correlation between phenolic content and oxidative stress cell protection

Cited by 39 publications

References 43 publications

Potential Beneficial Effects of Extra Virgin Olive Oils Characterized by High Content in Minor Polar Compounds in Nephropathic Patients: A Pilot Study

Potential Beneficial Effects of Extra Virgin Olive Oils Characterized by High Content in Minor Polar Compounds in Nephropathic Patients: A Pilot Study

Oxygenic metabolism in nutritional obesity induced by olive oil. The influence of vitamin C

Anti-GPC3 antibody-modified sorafenib-loaded nanoparticles significantly inhibited HepG2 hepatocellular carcinoma

Contact Info

Product

Resources

About