Oxygenic metabolism in nutritional obesity induced by olive oil. The influence of vitamin C

Drehmer, Eraci; Navarro-Moreno, Mari Ángeles; Carrera, S.; Villar, Vincent M.; Sancho, Mari Luz Moreno

doi:10.1039/c8fo02550a

Cited by 7 publications

(6 citation statements)

References 115 publications

(113 reference statements)

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“…Drehmer and collaborators (2019) [ 61 ] have reported that olive oil, which has a similar composition to the oil in this study, is one of the main components of the Mediterranean diet, which is famous for its ability to decrease body weight, the index of body mass and the waist and hip circumferences. Among the mechanisms potentially responsible for this reduction in body weight are the activation of β-oxidation, the induction of satiety, stimulation of energy expenditure by inducing thermogenesis in brown adipose tissue, the inhibition of adipocyte differentiation, the promotion of adipocyte apoptosis, and the increasing of lipolysis [ 62 ].…”

Section: Discussionsupporting

confidence: 55%

“…However, these effects of olive oil are only optimized when it is consumed in association with an adequate and balanced diet and physical activity, and when excessive levels of fat are included in the diet, even supplementation with olive oil cannot prevent the onset of obesity, which explains the results of our study in both the HPL OM and HPL AZ groups [ 61 ] ( Figure 7 ).…”

Section: Discussionmentioning

confidence: 99%

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Effects of the Seed Oil of Carica papaya Linn on Food Consumption, Adiposity, Metabolic and Inflammatory Profile of Mice Using Hyperlipidic Diet

et al. 2022

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Background: Studies indicate that different parts of Carica papaya Linn have nutritional properties that mean it can be used as an adjuvant for the treatment of various pathologies. Methods: The fatty acid composition of the oil extracted from the seeds of Carica papaya Linn was evaluated by gas chromatography, and an acute toxicity test was performed. For the experiment, Swiss mice were fed a balanced or high-fat diet and supplemented with saline, soybean oil, olive oil, or papaya seed oil. Oral glucose tolerance and insulin sensitivity tests were performed. After euthanasia, adiposity, glycemia, total cholesterol and fractions, insulin, resistin, leptin, MCP-1, TNF-α, and IL-6 and the histology of the liver, pancreas, and adipose tissue were evaluated. Results: Papaya seed oil showed predominance of monounsaturated fatty acids in its composition. No changes were observed in the acute toxicity test. Had lower food intake in grams, and caloric intake and in the area of adipocytes without minimizing weight gain or adiposity and impacting the liver or pancreas. Reductions in total and non-HDL-c, LDL-c, and VLDL-c were also observed. The treatment had a hypoglycemic and protective effect on insulin resistance. Supplementation also resulted in higher leptin and lower insulin and cytokine resistance. Conclusions: Under these experimental conditions, papaya seed oil led to higher amounts of monounsaturated fatty acids and had hypocholesterolemic, hypotriglyceridemic, and hypoglycemic effects.

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Section: Discussionsupporting

confidence: 55%

Section: Discussionmentioning

confidence: 99%

Effects of the Seed Oil of Carica papaya Linn on Food Consumption, Adiposity, Metabolic and Inflammatory Profile of Mice Using Hyperlipidic Diet

et al. 2022

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“…SOD neutralizes superoxide anion (O 2 ·− ) into less noxious hydrogen peroxide (H 2 O 2 ). H 2 O 2 is further metabolized to water and oxygen in the presence of CAT and GSH‐Px (Drehmer et al., 2019). The decline of SOD, CAT, and GSH‐Px activity is an impaired indicator of the protective mechanisms.…”

Section: Resultsmentioning

confidence: 99%

Synergistic effect of docosahexaenoic acid or conjugated linoleic acid with caffeic acid on ameliorating oxidative stress of HepG2 cells

Liu

Bian

Luo

et al. 2021

Journal of Food Science

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Exploring the synergistic effect of docosahexaenoic acid (DHA) or conjugated linoleic acid (CLA) with caffeic acid (CA) on ameliorating oxidative stress, thereby introducing CA to DHA or CLA will contribute significantly to enhance the bioactivity. We observed that DHA or CLA with CA promoted the recovery of intact individual morphology and the decline of cavities inside the nucleus and apoptosis under the observation of confocal laser scanning microscopy and fluorescent inverted microscope. The activity of intracellular antioxidant enzymes catalase (CAT) and glutathione peroxidase (GSH‐Px), lactate dehydrogenase (LDH) leakage, pyruvate and malondialdehyde and reactive oxygen species (ROS), cellular morphology, and cell cycle were analyzed. Our results showed that DHA or CLA with CA enhanced the activity of CAT and GSH‐Px, decreased LDH leakage and the number of apoptotic, significantly inhibited (ROS‐induced cellular injury. Cell arrest in G1 and G2 phase during cell mitosis was reduced by the measurement of flow cytometry. DHA or CLA combined with CA could markedly strengthen the free radical scavenging and endogenous antioxidant defense capacity on HepG2 cells. This study provides a new direction in the application of synergies to antioxidant compounds. Practical Application Caffeic acid (CA) can synergize with docosahexaenoic acid (DHA) or conjugated linoleic acid (CLA) to enhance antioxidant capacity. This study highlighted an effect of ameliorating oxidative stress injury DHA or CLA with CA on HepG2 cells. The data indicated that DHA or CLA with CA might be used to relieve oxidative stress damage.

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“…In terms of the impact and influence of dietary intakes on the level of inflammation, we must highlight the fact that an excessive intake of lipids is related to oxidative stress and inflammation [43,44]. In addition, at a clinical level, one of the main symptoms of the disease is the motor-level alterations related to anthropometric alterations observed in the disease [45].…”

Section: Discussionmentioning

confidence: 99%

The Relation between Eating Habits and Abdominal Fat, Anthropometry, PON1 and IL-6 Levels in Patients with Multiple Sclerosis

et al. 2020

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Background: Multiple sclerosis (MS) is a chronic neurodegenerative disease of an inflammatory, demyelinating and autoimmune nature. Diets with a high caloric density could be especially relevant in terms of the pathogenesis related to an increase in adipose tissue that is metabolically active and releases mediators, which can induce systemic inflammation and an increased oxidation state. The aim of this study was to analyse the eating habits related to calorie intake and their impact on abdominal obesity associated with anthropometric variables, the activity of the oxidation marker paraoxonase 1 (PON1), and interleukin 6 (IL-6) levelsin MS patients. Methods: An analytical and quantitative observational study was conducted with a population of 57 MS patients. The dietary-nutritional anamnesis was gained through the Food Frequency Questionnaire and a food diary. Diet and eating habits have been analysed through the Easy Diet–Programa de gestión de la consulta® software. Anthropometric measurements were taken in order to determine the presence of abdominal obesity. In addition, PON1 was quantified in serum by means of automated spectrophotometric assays and IL-6 was quantified using the ELISA technique. Results: A normal calorie intake was determined for women, yet a slightly lower intake was observed in men. Carbohydrate consumption was below what was established, and protein and lipids were over, in both cases. Furthermore, most patients had abdominal obesity, with significantly higher body mass index (BMI), waist-to-hip ratio (WHR), waist-to-height ratio (WHtR), fat percentage and IL-6 levels. IL-6 is greatly correlated with waist circumference and WHtR. Conclusion: MS patients’ nutrient intake shows an imbalance between macronutrients. This seems to favour the abdominal obesity associated with high values of proinflammatory IL-6 that is not correlated with a lower activity of PON1.

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Oxygenic metabolism in nutritional obesity induced by olive oil. The influence of vitamin C

Abstract: Obesity is a medical and sociological problem of great importance due to the high percentage of people affected and the important health consequences that it involves.

Cited by 7 publications

References 115 publications

Effects of the Seed Oil of Carica papaya Linn on Food Consumption, Adiposity, Metabolic and Inflammatory Profile of Mice Using Hyperlipidic Diet

Effects of the Seed Oil of Carica papaya Linn on Food Consumption, Adiposity, Metabolic and Inflammatory Profile of Mice Using Hyperlipidic Diet

Synergistic effect of docosahexaenoic acid or conjugated linoleic acid with caffeic acid on ameliorating oxidative stress of HepG2 cells

The Relation between Eating Habits and Abdominal Fat, Anthropometry, PON1 and IL-6 Levels in Patients with Multiple Sclerosis

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