Introduction: Several studies have shown an association between infection with Epstein-Barr virus (EBV) and the occurrence of many cancers in humans, including certain gastric carcinomas (GC). Indeed, recent studies have reported that 10% of CGs are associated with EBV. Materials and Methods: Samples of gastric carcinomatous tissues (biopsies and surgical specimens) were analyzed by PCR for the detection of EBV. Samples were collected retrospectively between January 2008 and December 2018. Results: during this period, 52 samples were analyzed. PCR results show the EBV infection rate to be 3.8%. Conclusion: The results obtained during this preliminary study confirm the association of EBV in 3.8% of CG cases, which is consistent with the data in the literature. Key words: EBV, gastric carcinoma, PCR.
Introduction: Gastric adenocarcinoma is the most common gastric malignancy (over 90% of gastric cancers) and remains a global public health problem. The aim of the study was to determine the epidemiological and histopathological aspects of gastric adenocarcinoma in Brazzaville. Material and Methods: The epidemiological and histopathological profile is determined through a descriptive study, collecting retrospective data spread over a period of 11 years (January 2008- December 2018), based on consultation of the departmental histology registers. pathological anatomy and cytology. For each case, age, sex, location, pTNM stage, location and histological type were collected. Results: 93 histologically confirmed gastric adenocarcinomas were collected during the 11-year period. The mean age of the patients was 54.5 years. The sex ratio was 2 in favor of men. The antral and fundal localization were more frequent (74.2% and 20.4% respectively). Of the 2 operative parts collected, one was T2N1 and the other T1N0. Tubular adenocarcinoma was the most common histologic type (51.6%), followed by independent cell adenocarcinoma (34.4%), papillary adenocarcinoma (11.8%), and mucinous adenocarcinoma (2, 2%). Conclusion: gastric tubular adenocarcinoma was the most common histological type in Brazzaville. Key words: epidemiology, gastric adenocarcinoma, histological type.
Introduction: The Epstein Barr virus (EBV) is associated with a variety of human malignancies including gastric cancer (GC). Several studies have shown an association between Epstein-Barr virus (EBV) infection and the occurrence of many cancers in humans, including certain gastric carcinomas (GC). Indeed, recent studies have reported that 10% of GCs are associated with EBV. There is no study on the association of EBV with CG in Brazzaville. The aim of the study was to detect EBV DNA in gastric adenocarcinoma in Brazzaville. Materials and Methods: Samples of carcinomatous gastric tissues were analyzed by qPCR to detect EBV DNA. The samples were collected retrospectively between January 2008 and December 2018. Results: Fifty two samples were analyzed. The PCR results showed that the detection of EBV DNA on our sample was 3.8%. Conclusion: The results obtained from this preliminary study confirm the presence of EBV DNA in gastric adenocarcinoma, which is consistent with data from the literature. Key words: DNA, EBV, gastric adenocarcinoma, qPCR.
Introduction: Gastric cancer is predominantly represented by adenocarcinoma, which is the most common histological type. The latter develops from the gastric epithelium and remains a global public health problem. The aim of the study was to assess the overexpression of the Her2 biomarker of gastric adenocarcinoma in Brazzaville. Materials and Methods: Samples of gastric carcinomatous tissues (paraffin blocks) were analyzed by the manual immunohistochemistry technique for the evaluation of the Her2 biomarker. Samples were collected retrospectively between January 2008 and December 2018. Results: during this period, 52 samples were analyzed. The immunohistochemistry results show that the Her2 protein positivity rate in adenocarcinoma cases was 9.6%. Conclusion: The results obtained during this preliminary study confirm the presence of the Her2 biomarker in 9.6% of gastric adenocarcinoma cases, which is consistent with the data in the literature. Key words: Her2, Gastric adenocarcinoma, Immunohistochemistry.
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