Detection of Epstein Barr Virus DNA in Gastric Adenocarcinoma in Brazzaville

Abstract

Introduction: The Epstein Barr virus (EBV) is associated with a variety of human malignancies including gastric cancer (GC). Several studies have shown an association between Epstein-Barr virus (EBV) infection and the occurrence of many cancers in humans, including certain gastric carcinomas (GC). Indeed, recent studies have reported that 10% of GCs are associated with EBV. There is no study on the association of EBV with CG in Brazzaville. The aim of the study was to detect EBV DNA in gastric adenocarcinoma in Brazzaville. Materials and Methods: Samples of carcinomatous gastric tissues were analyzed by qPCR to detect EBV DNA. The samples were collected retrospectively between January 2008 and December 2018. Results: Fifty two samples were analyzed. The PCR results showed that the detection of EBV DNA on our sample was 3.8%. Conclusion: The results obtained from this preliminary study confirm the presence of EBV DNA in gastric adenocarcinoma, which is consistent with data from the literature. Key words: DNA, EBV, gastric adenocarcinoma, qPCR.