There was no effect of gender on serum cystatin C, as well as on measured and estimated GFR.

The human hair follicle, a mini-organ formed with neuroectodermal-mesodermal interaction, is a complex structure, in the active steady state (anagen) the dermal papilla can be considered as a ball of extracellular matrix, surrounding specialized fibroblasts. The cross-talk of dermal papilla with neighbouring matrix cells results in the maintenance of hair fibre production. This study aimed to investigate the proliferative potential of the compound Trichotech TM , a phytocomplex obtained from a mixture of essential oils, on cultured human fibroblasts and its ability to modulate the gene expression of FGF-7 and FGF-10. Trichotech TM was shown to enhance fibroblasts proliferation in concentrations of 0.5% to 2.0%, and also increase the percentage of cells in the S/G2/M phases of the cell cycle. Trichotech TM at both 1.0% and 2.0% induced a statistically significant effect on wound healing assay compared to the untreated control. We examined the interaction between cell survival (PI3K/Akt) and mitogenic (Ras/MAPK) signal transduction pathways after Trichotech TM treatment (1.0% and 2.0%) on the fibroblast cell line.

Background: Most anxiety complaints are treated with pharmacological measures involving barbiturates and benzodiazepines, in which they may end up causing tolerance and pharmacological dependence. Integrative approaches such as aromatherapy are used in addition to medications to improve sleep quality and reduce anxiety. Thus, Pinetonin™, a phytocomplex obtained from a blend of essential oils aims to aid in the symptoms of stress and anxiety. Methods: The cytotoxicity of Pinetonin™ was evaluated MTT assay using fibroblasts and astrocytes showed reduction in the cell viability only at high concentrations. Evaluation of intracellular calcium and determination of residual glutamate in the supernatant of astrocyte cultures showed agonist action of dihydroxyphenylglycine (DHPG) increasing linearly the concentration of intracellular calcium and the glutamate levels in the supernatants of the cultures. On the other hand, cultures of astrocytes treated with Pinetonin™ showed residual glutamate levels in the supernatants reducing proportionally, as well as, intracellular calcium reduction. The determination of salivary cortisol showed a significant reduction in salivary cortisol levels in the group that received Pinetonina™.

Core needle biopsy represents a safe and cheap alternative diagnostic method to open biopsy and fine-needle aspiration cytology in head and neck tumors. There is little evidence in the literature about the use of core needle biopsy in minor salivary gland lesions. This single case report presents a 60-year-old woman with a painless swelling in the soft palate, breathing and swallowing difficulties, and a feeling of suffocation. Two open biopsies had inconclusive diagnosis and the lesion could only be assessed and diagnosed as pleomorphic adenoma through core needle biopsy. Recognizing the correct indication of core needle biopsy can benefit both health professionals and patients; thus, it is important to consider the possibility of performing this method to diagnose minor salivary gland tumors.

Fatores de risco associados à saúde dos dentistas -uma abordagem epidemiológica

No abstract

O diabete melito produz muitas alterações complexas na vida de seus portadores. O nível elevado de glicose no sangue, que pode ocorrer na ausência de sintomas, leva a complicações posteriores devido aos danos teciduais. Nos últimos dez anos, diversos estudos vem apontando para uma relação entre o diabete melito e várias doenças e desordens tanto sistêmicas quanto orais. Além disso, infecções crônicas por si só podem contribuir para o aumento dos níveis de glicose no sangue e, por esta razão, surgem as complicações posteriores do diabete. As doenças orais mais comuns associadas ao diabete melito são a doença periodontal, cicatrização de feridas dificultada, neuropatia oral, fluxo salivar reduzido, cárie dental e candidíase oral. Achados recentes sugerem que a equipe odontológica pode contribuir muito nos cuidados aos diabéticos com a equipe de atenção ao diabético em si. O objetivo desta revisão é apontar as manifestações estomatológicas relacionadas ao diabete melito.