Background: The atherogenic index of plasma (AIP) is the base-10 logarithmic conversion of the triglyceride to high-density lipoprotein cholesterol ratio [AIP = log10 (triglyceride/HDL cholesterol)]. Some studies have found a link between low serum vitamin D levels, AIP, and fatty liver. This study was conducted to evaluate the relationship between AIP levels, fatty liver, and vitamin D levels in obese adolescents aged 10–17 years. Methods: This study included 136 adolescents, including 83 obese and 53 healthy controls, in the age range of 10–17 years. Thirty-nine of the obese adolescents had fatty livers. Those with ultrasonography grades 2 or 3 of fat were in the fatty liver group. The AIP value was calculated as the logarithmic conversion of the ratio (triglyceride/HDL cholesterol) at the base of 10. Vitamin D and other laboratory tests were analyzed biochemically. Statistical evaluations were made with the SPSS program. Results: The AIP, body mass index (BMI), homeostatic model assessment for insulin resistance (HOMA-IR), and insulin averages of obese adolescents with fatty liver were significantly higher than those of obese adolescents without fatty liver and the healthy control group (p < 0.05). Again, the mean AIP of obese patients without fatty liver was pointedly higher than that of the healthy control group (p < 0.05). There was a positive, moderate relationship between AIP and BMI, AIP and HOMA-IR, and AIP and insulin levels (p < 0.05), whereas there was a negative, moderate (37.3%) relationship between AIP and vitamin D (p = 0.019). Conclusion: AIP levels were higher in obese adolescents, and this increase was higher in obese adolescents with fatty liver in this study. Moreover, we detected a negative correlation between AIP and vitamin D levels and a positive correlation with BMI, insulin resistance, and insulin levels. Based on our data, we concluded that AIP can be a useful predictor of fatty liver in obese adolescents.
Amaç: COVID-19 tanılı hastalarda glipikan-3 düzeylerini belirlemeyi, bu değerleri sağlıklı kontrollerle karşılaştırmayı; ayrıca glipikan-3 düzeylerinin interlökin-6 (IL-6) dahil inflamatuar belirteçlerle ilişkisini ve hastalık patogenezindeki rolünü belirlemeyi amaçladık. Gereç ve Yöntem: Çalışmaya toplam 88 olgu (58 hasta ve 30 kontrol) dahil edildi. Olguların tıbbi öyküsü ve laboratuvar bulguları kaydedildi. Serum glipikan-3 ve IL-6 seviyeleri Enzim-bağlı immünosorbent ölçüm yöntemi ile analiz edildi. Bulgular: Alanin aminotransferaz (ALT), aspartat aminotransferaz (AST), C-reaktif protein (CRP), D-dimer, ferritin, laktat dehidrojenaz (LDH) ve IL-6 seviyeleri COVID-19 hasta grubunda sağlıklı kontrollere göre anlamlı derecede yüksek bulunurken, glipikan-3 seviyeleri hasta grubunda anlamlı derecede daha düşüktü (p <0,001). Glipikan-3 seviyeleri, serum AST, CRP, ferritin, IL-6 ve LDH seviyeleri ile anlamlı ve ters korelasyon gösterdi (p<0.05). Sonuç: COVID-19 hastalarında glipikan-3 düzeylerinin daha düşük olduğunu bulduk. Ek olarak, serum glipikan-3 seviyeleri, CRP ve IL-6 seviyeleri ile ters ilişkilidir. Glipikan-3' ü hedeflemek, COVID-19'un patofizyolojisini anlamada faydalı olabilir.
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